ArticleVeterinary sciences2026
Exploratory Spatial Lipidomic Profiling Reveals Regional Metabolic Heterogeneity in a Canine Mixed Mammary Carcinoma.
Article in Veterinary sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Canine mixed-type mammary carcinomas (CMTs) exhibit remarkable histological and structural heterogeneity, sharing some biological similarities with human breast cancer and supporting their relevance as models in comparative oncology. These tumors frequently contain regions of malignant epithelial cells, areas of mesenchymal differentiation, and ossified tissue, reflecting their complex histological organization. In this exploratory pilot study, we performed MRM-based spatial lipidomic analysis of distinct tumor regions; namely the margin, middle (epithelial/myoepithelial-rich), and central ossified areas. Our region-resolved lipidomic analysis revealed distinct lipidomic signatures across regions, with significant alterations in phosphatidylcholines, phosphatidylethanolamines, sphingomyelins, triacylglycerides, and free fatty acids distribution. The central ossified area showed enrichment in structural lipids and ceramides, while the tumor margin demonstrated enrichment of ether lipids, which may reflect differences in tissue composition and local metabolic environments. By characterizing region-specific lipid profiles, this study provides insights into metabolic heterogeneity within a canine mixed mammary carcinoma. These findings highlight the potential of spatial lipidomics for investigating intratumoral metabolic heterogeneity and provide preliminary data to support future studies in comparative oncology involving canine and human mammary tumors.
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