ReviewPolymers2026
Polymeric Biomaterials for the Delivery of Stem Cell-Derived Exosomes in Inflammatory Skin Diseases: Engineering Strategies and Synergistic Effects.
Review in Polymers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Skin tissue engineering has emerged as a promising therapeutic strategy for severe wounds and inflammatory skin diseases. Stem cell-derived exosomes (SC-Exos) have recently gained increasing attention as cell-free therapeutic agents with regenerative and immunomodulatory potential, offering possible advantages over direct stem cell transplantation. To fully realize their therapeutic potential, however, efficient delivery platforms are needed to enhance local retention, preserve vesicle integrity, and support sustained release within the diseased skin microenvironment. In this review, we discuss advanced polymeric biomaterials as functional delivery platforms for SC-Exos in skin tissue engineering. We focus on natural and synthetic polymers engineered into nanofibrous scaffolds, hydrogels, and microneedles, and examine how these systems enhance exosome loading, protect vesicle integrity, improve local retention, and modulate release kinetics. We further highlight the therapeutic effects and underlying mechanisms of polymer-exosome systems in skin lesion repair, focusing on their roles in promoting angiogenesis, modulating local inflammation and immune responses, and facilitating extracellular matrix remodeling. Finally, we address remaining challenges and future directions for translating polymer-based SC-Exos delivery platforms into clinically relevant skin regenerative therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.