Evidence map›Paper›PMID 42514857›Full record

ReviewPharmaceutics2026

Promising Natural Polymer-Based Dressings for Diabetic Foot Ulcers: Mechanisms, Preclinical Studies, and Clinical Applications.

Yixuan Fang, Jing Wu, Shiyi Sun, Yan Li, Xingwu Ran

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yixuan FangDepartment of Endocrinology & Metabolism, West China Hospital, Sichuan University, Chengdu 610041, China.ORCID 0009-0007-2488-548X
Jing WuDepartment of Endocrinology & Metabolism, West China Hospital, Sichuan University, Chengdu 610041, China.ORCID 0009-0007-3764-8918
Shiyi SunDepartment of Endocrinology & Metabolism, West China Hospital, Sichuan University, Chengdu 610041, China.
Yan LiDepartment of Endocrinology & Metabolism, West China Hospital, Sichuan University, Chengdu 610041, China.ORCID 0000-0002-5134-9785
Xingwu RanDepartment of Endocrinology & Metabolism, West China Hospital, Sichuan University, Chengdu 610041, China.ORCID 0000-0002-6634-1241

Funding

Science and Technology Department of Sichuan Province No. 2024YFFK0290Science and Technology Department of Sichuan Province No. 2025ZNSFSC1621the Health Commission of Sichuan Province No. 23LCYJ042West China Hospital of Sichuan University No. 2025HXBH098West China Hospital of Sichuan University No. GYYX24002West China Hospital of Sichuan University No. ZYGD24005
6 · The paper itself

Abstract

Diabetic foot ulcers (DFUs) are among the most severe complications affecting diabetic patients, and dressing therapy is one of the standard treatments for DFUs. However, traditional dressings are inadequate for addressing the complex microenvironment of DFUs. Consequently, advanced natural polymer-based dressings have attracted extensive research attention in diabetic foot care due to their biocompatibility, low immunogenicity, and biodegradability. These natural polymer materials include collagen, gelatin, chitosan (CS), hyaluronic acid (HA), alginate, and cellulose. This review systematically analyzes the pathophysiological mechanisms underlying the difficult healing of DFUs and the advantages of natural polymer-based dressings in diabetic wound healing, highlights preclinical studies, and synthesizes evidence from clinical research. Moreover, we pinpoint the challenges associated with these dressings and propose future directions for the improvement of diabetic wound care.

Indexed as

diabetesdressingnatural polymerwound healing

Identifiers

PMID42514857
PMCPMC13415149

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.