Evidence mapPaperPMID 42514899Full record

ReviewPharmaceutics2026

Beyond Antibiotics: The Role of Antimicrobial Polymers in Modern Therapeutics.

Martina Appignani, Giovanni Corfiati, Lisa Marinelli, Marilisa Pia Dimmito, Antonio Di Stefano, Ivana Cacciatore

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Martina AppignaniDepartment of Pharmacy, "G. d'Annunzio" University of Chieti-Pescara, Chieti Scalo, 66100 Chieti, Italy.
Giovanni CorfiatiDepartment of Pharmacy, "G. d'Annunzio" University of Chieti-Pescara, Chieti Scalo, 66100 Chieti, Italy.ORCID 0009-0004-1299-4273
Lisa MarinelliDepartment of Pharmacy, "G. d'Annunzio" University of Chieti-Pescara, Chieti Scalo, 66100 Chieti, Italy.ORCID 0000-0001-8611-6538
Marilisa Pia DimmitoDepartment of Pharmacy, "G. d'Annunzio" University of Chieti-Pescara, Chieti Scalo, 66100 Chieti, Italy.ORCID 0000-0002-9381-7196
Antonio Di StefanoDepartment of Pharmacy, "G. d'Annunzio" University of Chieti-Pescara, Chieti Scalo, 66100 Chieti, Italy.ORCID 0000-0002-3042-2234
Ivana CacciatoreDepartment of Pharmacy, "G. d'Annunzio" University of Chieti-Pescara, Chieti Scalo, 66100 Chieti, Italy.ORCID 0000-0001-6253-0443

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial polymers are a potential and viable alternative to antibiotic therapies, whose effectiveness is increasingly compromised by the onset of antimicrobial resistance and antibiotic persistence. Antimicrobial polymers also have potential in the formulation of new drug delivery systems. Difficulties in finding new naturally derived compounds and classes of antimicrobials pose a major threat to public health and have made finding an alternative crucial. The aim of this review is to provide a comprehensive overview of the antimicrobial polymers currently available, whether of natural or synthetic origin, and to explore their use in pharmaceutical formulations, including a brief description of their preparation methods. Furthermore, a critical assessment of the advantages, limitations, and potential future developments of these systems will be presented, with particular attention to their clinical applicability, safety profiles, and role in combating antimicrobial resistance. Finally, the review highlights key challenges and future directions for the clinical translation of antimicrobial polymer-based systems, with a focus on safety, scalability, and their potential role in addressing antimicrobial resistance.

Indexed as

antibioticantibiotic resistanceantimicrobial polymerbiofilm

Identifiers

PMID42514899
PMCPMC13415135

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.