Evidence mapPaperPMID 42514957Full record

ReviewPharmaceutics2026

Advances in Functional Vascular Stents for Cardiovascular Therapy with Drug Delivery and Computational Design.

Xiaotian Xu, Yan Hu, Haifang Li, Yu Wang, Jiayi Sun, Qiang Liu, Kairong Qin

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaotian XuCentral Hospital, Dalian University of Technology, Dalian 116089, China.
Yan HuSchool of Software Technology, Dalian University of Technology, Dalian 116024, China.
Haifang LiDepartment of AI and Informatics, Mayo Clinic, Jacksonville, FL 32224, USA.
Yu WangFaculty of Medicine, Dalian University of Technology, Dalian 116024, China.ORCID 0000-0001-6690-8810
Jiayi SunCentral Hospital, Dalian University of Technology, Dalian 116089, China.
Qiang LiuCentral Hospital, Dalian University of Technology, Dalian 116089, China.ORCID 0000-0003-4624-7466
Kairong QinFaculty of Medicine, Dalian University of Technology, Dalian 116024, China.ORCID 0000-0001-6781-2941

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vascular stents are crucial devices in the treatment of cardiovascular diseases, and their structural design and function critically affect therapeutic efficacy and patient prognosis. Conventional stents can effectively restore vascular patency by providing mechanical support to blood vessels. However, they still face significant challenges including restenosis, thrombosis, and limited adaptability to complex patient-specific lesion characteristics. To address these limitations, drug delivery offers an important strategy to modulate the pathological microenvironment, enhance long-term vascular healing, and reduce systemic side effects. Meanwhile, advances in computational simulations have provided powerful tools for optimizing stent design through structural mechanics, hemodynamics, and drug release modeling. Computational approaches enable the rational design of stent architectures with improved mechanical stability, vascular compatibility, and therapeutic regulation. Consequently, the development of vascular stents is evolving toward the synergistic integration of drug delivery, structural optimization, and intelligent design. This review summarizes the latest advances in functional vascular stents, clinical applications and computational design. This work aims to provide valuable insights for the engineering of efficient, precise, and intelligent vascular stents for cardiovascular therapies.

Indexed as

computational designdrug deliveryhemodynamicsvascular stents

Identifiers

PMID42514957
PMCPMC13414956

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.