Evidence map›Paper›PMID 42515100›Full record

ArticlePathogens (Basel, Switzerland)2026

Investigation of the Anti-

Stephanie Ortega Alves, Ingrid de Oliveira Dias, Gabriel Candido Moura, Samuel Cota Teixeira, Juliana Quero Reimão

Abstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Stephanie Ortega AlvesLaboratory of Preclinical Assays and Research of Alternative Sources of Innovative Therapy for Toxoplasmosis and Other Sicknesses (Lab. PARASITTOS), Faculdade de Medicina de Jundiaí, Jundiaí 13202-550, Brazil.
Ingrid de Oliveira DiasLaboratory of Preclinical Assays and Research of Alternative Sources of Innovative Therapy for Toxoplasmosis and Other Sicknesses (Lab. PARASITTOS), Faculdade de Medicina de Jundiaí, Jundiaí 13202-550, Brazil.
Gabriel Candido MouraLaboratory of Preclinical Assays and Research of Alternative Sources of Innovative Therapy for Toxoplasmosis and Other Sicknesses (Lab. PARASITTOS), Faculdade de Medicina de Jundiaí, Jundiaí 13202-550, Brazil.ORCID 0000-0002-1256-057X
Samuel Cota TeixeiraLaboratory of Immunophysiology of Reproduction, Institute of Biomedical Science, Universidade Federal de Uberlândia, Uberlândia 38405-320, Brazil.ORCID 0000-0002-1978-1658
Juliana Quero ReimãoLaboratory of Preclinical Assays and Research of Alternative Sources of Innovative Therapy for Toxoplasmosis and Other Sicknesses (Lab. PARASITTOS), Faculdade de Medicina de Jundiaí, Jundiaí 13202-550, Brazil.ORCID 0000-0002-4418-0838

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 404478/2025-5Coordenação de Aperfeicoamento de Pessoal de Nível Superior 88887.162302/2025-00Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/18954-4Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/03399-5Fundação de Amparo à Pesquisa do Estado de São Paulo 2023/18327-8Fundação de Amparo à Pesquisa do Estado de São Paulo 2024/22547-6
6 · The paper itself

Abstract

Toxoplasmosis remains a major global health concern, particularly in immunocompromised individuals and pregnant women, while currently available therapies are associated with significant toxicity and limited efficacy against chronic infection. Drug repurposing represents an attractive strategy for the identification of safer and more effective anti-

Indexed as

Antiprotozoal AgentsLoratadineToxoplasmaToxoplasmosisAnimalsDisease Models, AnimalDrug RepositioningFemaleHumansMiceAntiprotozoal AgentsLoratadineantihistaminesdrug repurposingin vivo efficacyloratadineToxoplasma gondiitoxoplasmosis

Identifiers

PMID42515100
PMCPMC13415111

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.