Evidence map›Paper›PMID 42515629›Full record

ArticleViruses2026

Susceptibility of Cell Lines from Different Species to Porcine Deltacoronavirus.

Hui Jiang, Baoguo Lu, Yimin Chu, Mingyue Ma, Nannan Zhang, Yanyan Xu, Yanying Chen, Qingyang Xiao, Ting Wang, Qi Peng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hui JiangCollege of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.
Baoguo LuInstitute of Pathogenic Microorganism, Jiangxi Agricultural University, Nanchang 330045, China.
Yimin ChuInstitute of Pathogenic Microorganism, Jiangxi Agricultural University, Nanchang 330045, China.
Mingyue MaInstitute of Pathogenic Microorganism, Jiangxi Agricultural University, Nanchang 330045, China.
Nannan ZhangInstitute of Pathogenic Microorganism, Jiangxi Agricultural University, Nanchang 330045, China.
Yanyan XuInstitute of Pathogenic Microorganism, Jiangxi Agricultural University, Nanchang 330045, China.
Yanying ChenInstitute of Pathogenic Microorganism, Jiangxi Agricultural University, Nanchang 330045, China.
Qingyang XiaoSchool of Medical and Information Engineering, Gannan Medical University, Ganzhou 341000, China.
Ting WangInstitute of Pathogenic Microorganism, Jiangxi Agricultural University, Nanchang 330045, China.
Qi PengInstitute of Pathogenic Microorganism, Jiangxi Agricultural University, Nanchang 330045, China.ORCID 0000-0002-8128-1697

Funding

Jiangxi Provincial Natural Science Foundation 20232BAB215001Jiangxi Provincial Natural Science Foundation 20242BAB23068National Natural Science Foundation of China 32202823National Natural Science Foundation of China 32503078National Natural Science Foundation of China 32560869
6 · The paper itself

Abstract

Porcine deltacoronavirus (PDCoV) is an emerging swine enteric coronavirus that causes severe diarrhea in piglets, leading to extensive economic losses in the global swine industry. Previous studies have reported that PDCoV can experimentally infect multiple animal species. However, the replication capability of PDCoV in non-natural host cell lines remains largely unknown. Herein, we investigated the effects of exogenous trypsin on PDCoV replication and systematically evaluated the susceptibility of various cell lines derived from human, murine, and feline to PDCoV. The results showed that highly permissive cell lines (H1299, Caco-2, MC-38) supported efficient viral replication without the requirement for exogenous trypsin, and high concentrations of trypsin induced prominent syncytia formation in infected H1299, U251, and Neuro-2a cells. Furthermore, this study also found that trypsin can enhance PDCoV replication in a concentration-dependent manner in semi-permissive cell lines. PDCoV can replicate in multiple cell lines of human, murine, and feline origin. Human cells (H1299, Caco-2) and murine MC-38 are highly susceptible to PDCoV infection, whereas MCF-7, TE-10, and KYSE-410 cells were completely non-permissive. The results also revealed a potential correlation between basal APN expression and cellular susceptibility to PDCoV. Collectively, this study provides a basis for assessing the interspecies transmission and zoonotic risk of PDCoV.

Indexed as

Coronavirus InfectionsDeltacoronavirusSwine DiseasesVirus ReplicationAnimalsCaco-2 CellsCatsCell LineHumansMiceSwineTrypsinTrypsinaminopeptidase Ncell line susceptibilityporcine deltacoronavirustrypsin

Identifiers

PMID42515629
PMCPMC13431601

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.