ReviewViruses2026
Age-Dependent Differences in the Antiviral Response of the Respiratory Epithelium.
Review in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Age is an established risk factor for severe viral respiratory infections, yet the mechanisms driving increased severity of illness in infants and older adults remain incompletely understood. The respiratory epithelium is the primary target of viral infection and how it orchestrates the immune response may be a key determinant of clinical outcomes. The profound age-related difference in susceptibility to severe Coronavirus disease 2019 (COVID-19) brought increased attention to the epithelial response to viral infection in children and adults, adding significant data to the preexisting body of work largely focused on influenza and respiratory syncytial virus (RSV). This review synthesizes current knowledge on the structural and functional differences in the respiratory epithelium between children and adults at baseline and during viral infection. We review the variable and heterogenous human studies in addition to in vitro and animal model data to identify key gaps in current knowledge. Here, we advocate for a more complete understanding of age-dependent differences in the respiratory epithelial response to viral infection to uncover therapeutic targets for prevention and treatment of viral-associated respiratory failure.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.