ArticleExperimental biology and medicine (Maywood, N.J.)2026
Genetic evidence for causal relationships between brain functional networks and domain-specific recovery after nondisabling ischemic stroke.
Article in Experimental biology and medicine (Maywood, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intrinsic brain networks are crucial for post-stroke recovery, but the causal relationships between specific networks and domain-specific recovery outcomes, as well as the role of lipid metabolism, remain unclear. This study leveraged Mendelian randomization (MR) to evaluate 191 resting-state functional magnetic resonance imaging (rs-fMRI) BOLD-derived phenotypes in relation to post-stroke recovery after nondisabling ischemic stroke. Genetic instruments for rs-fMRI phenotypes were derived from a UK Biobank genome-wide association study (n = 34,691). Outcomes included motor, cognitive, and global recovery after nondisabling ischemic stroke, assessed using longitudinal National Institutes of Health Stroke Scale subscales over 2 years (n = 1,270). Primary analyses used the multiplicative random-effects inverse-variance weighted method. A two-step MR analysis investigated whether brain networks mediate the effects of lipids on post-stroke outcomes. Higher BOLD-derived functional connectivity within the triple network (default mode network, central executive network, and salience network) was associated with better motor and cognitive outcomes. Higher genetically predicted orbitofrontal node amplitude in the limbic network correlated with better motor recovery, while stronger parieto-frontal connectivity was associated with cognitive recovery. Genetically proxied higher low-density lipoprotein cholesterol (LDL-C) was associated with poorer cognitive recovery, with evidence suggesting partial mediation through differences in BOLD-derived triple-network connectivity. This MR study supports a potential causal role of BOLD-derived functional network phenotypes, particularly the triple network, in motor and cognitive recovery, and further suggests that differences in triple-network connectivity act as a partial mediator linking elevated LDL-C liability to impaired cognitive recovery. These findings provide hypothesis-generating evidence for future mechanistic studies and for exploring whether specific brain network-targeted interventions could have a role in stroke recovery.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.