Evidence map›Paper›PMID 42516192›Full record

ArticleFrontiers in psychology2026

Effectiveness and cost-effectiveness of a guided internet-based Acceptance and Commitment Therapy intervention (MobACT) for adults with Chronic Pain in Italy: study protocol for a randomized controlled trial.

Michelle Semonella, Alberto De Luca, Carlotta Rodighiero, Gerhard Andersson, Monica Buhrman, Valeria Donisi, Anna Guerrini Usubini, Giulia Landi, Chiara Manna, Ilenia Pasini and 7 more

Registry-linked trialAbstract read
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In one paragraph

Article in Frontiers in psychology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07270588 (MOBACT), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07270588 narecruitingnot on this map

MOBACT: An Internet-Based Guided Self-Help Intervention Based on Acceptance and Commitment Therapy for Chronic Pain

TypeinterventionalSponsorCatholic University of the Sacred HeartRan2025 to 2027Enrolled140ConditionsChronic PainArmsInternet-based intervention
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Michelle SemonellaDepartment of Psychology, Catholic University of Milan, Milan, Italy.
Alberto De LucaDepartment of Psychology, University of Bologna, Bologna, Italy.
Carlotta RodighieroDepartment of Neuroscience, Biomedicine and Movement Science, University of Verona, Verona, Italy.
Gerhard AnderssonDepartment of Behavioural Science and Learning, Department of Biomedical and Clinical Sciences, Linköping University, Sweden.
Monica BuhrmanDepartment of Psychology, Uppsala University, Sweden.
Valeria DonisiDepartment of Neuroscience, Biomedicine and Movement Science, University of Verona, Verona, Italy.
Anna Guerrini UsubiniClinical Psychology Research Laboratory, IRCCS Istituto Auxologico Italiano, Milan, Italy.
Giulia LandiDepartment of Psychology, University of Bologna, Bologna, Italy.
Chiara MannaFaculty of Psychology, Vita-Salute San Raffaele University, Milan, Italy.
Ilenia PasiniDepartment of Neuroscience, Biomedicine and Movement Science, University of Verona, Verona, Italy.
Cinzia PerliniDepartment of Neuroscience, Biomedicine and Movement Science, University of Verona, Verona, Italy.
Giada PietrabissaDepartment of Psychology, Catholic University of Milan, Milan, Italy.
Barbara SegattiniDepartment of Neuroscience, Biomedicine and Movement Science, University of Verona, Verona, Italy.
Eliana TossaniDepartment of Psychology, University of Bologna, Bologna, Italy.
Silvana GrandiDepartment of Psychology, University of Bologna, Bologna, Italy.
Lidia Del PiccoloDepartment of Neuroscience, Biomedicine and Movement Science, University of Verona, Verona, Italy.
Gianluca CastelnuovoDepartment of Psychology, Catholic University of Milan, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chronic Pain (CP) affects approximately one in five adults and is associated with emotional distress, disability, reduced productivity and substantial healthcare and societal costs. Acceptance and Commitment Therapy (ACT) has demonstrated effectiveness in improving emotional, behavioral and functional outcomes in individuals with CP, but access to ACT is frequently limited by geographic, organizational and workforce barriers. Internet-based interventions may help overcome these limitations by increasing accessibility, reducing treatment costs and improving scalability. Objective: This study evaluates the effectiveness and cost-effectiveness of MobACT, a guided internet-based ACT programme for Italian adults with CP. The primary effectiveness endpoint is the post-intervention assessment (T1). Methods and analysis: This two-arm randomized controlled trial will allocate adults with medically verified CP to either immediate MobACT or waitlist control (1:1). Participants in the waitlist control condition will receive access to MobACT only after completion of the T1 assessment, following the primary between-group comparison. A 6-month follow-up (T2) will be conducted in the intervention group only to examine maintenance of treatment effects. The primary outcome will be pain acceptance, assessed with the Chronic Pain Acceptance Questionnaire. Pain intensity and pain interference will be key clinical secondary outcomes. Additional secondary outcomes include quality of life, sleep quality, central sensitization, pain catastrophizing, psychological flexibility, self-efficacy, coping, anxiety, and depressive symptoms. Weekly assessments of sleep quality and changes in pharmacological treatment will also be collected during the active intervention period. The economic evaluation will compare the two conditions from healthcare and societal perspectives using service utilization data, productivity indicators, and EQ-5D-3L-derived quality-adjusted life years. Ethics and dissemination: Ethical approval was obtained from the Ethics Committee of Università Cattolica del Sacro Cuore, Milan (Approval No.: 146/24). Results will be disseminated through peer-reviewed publications, international conferences and stakeholder reports for patient organizations. Trial registration number: ClinicalTrials.gov Identifier: NCT07270588.

Indexed as

Acceptance and Commitment Therapy (ACT)Chronic Paincost-effectiveness analysisinternet-based interventionrandomized controlled trial

Identifiers

PMID42516192
PMCPMC13403208

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.