ArticleInternational journal of nanomedicine2026
A Surface-Engineered Cerium Oxide Nanozyme Functionalized with L-Theanine for Redox and Inflammatory Modulation in Neuropathic Pain.
Article in International journal of nanomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Neuropathic pain is associated with interacting oxidative stress-, neuroinflammation-, and apoptosis-related processes, whereas current therapies mainly provide symptomatic relief without fully addressing these pathological components. To overcome this limitation, we developed a surface-engineered nanozyme platform composed of poly(acrylic acid)-coated cerium oxide nanoparticles functionalized with L-theanine (CPT), aiming to combine the redox activity of nanoceria with the bioactivity of a neuroprotective small molecule. Results: Physicochemical characterization demonstrated that L-theanine functionalization did not alter the crystalline structure or mixed Ce Conclusion: These findings suggest that CPT attenuates oxidative stress-, inflammatory cytokine-, and caspase-3-associated responses in both H
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