ArticlePulmonary circulation2026
Invasive Hemodynamic Predictors of Outcomes in Rheumatic Heart Disease With Echocardiographic RV-PA Uncoupling: A Single-Center Retrospective Cohort Study.
Article in Pulmonary circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Rheumatic heart disease (RHD) is frequently complicated by pulmonary hypertension (PH) and right ventricular (RV) dysfunction. However, the prognostic significance of invasive hemodynamic parameters obtained at index right heart catheterization (RHC) in adults with RHD and echocardiographic RV-pulmonary artery (PA) uncoupling remains incompletely defined. We evaluated their associations with all-cause mortality and a composite adverse clinical outcome. We conducted a single-center retrospective cohort study of a clinically selected group of adults with RHD and echocardiographic RV-PA uncoupling who underwent index RHC for invasive hemodynamic assessment and pre-intervention risk stratification. Parsimonious multivariable logistic regression models were used to examine adjusted associations between selected invasive hemodynamic variables and study outcomes during the available hospital-record observation period. Among 56 patients, 14 (25.0%) died during the available hospital-record observation period after the index RHC, and 23 (41.1%) experienced the composite adverse clinical outcome. In parsimonious multivariable analysis, higher pulmonary vascular resistance (PVR) remained associated with all-cause mortality after adjustment (OR 1.573, 95% CI 1.012-2.447;
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