Evidence map›Paper›PMID 42517949›Full record

ArticleMetabolomics : Official journal of the Metabolomic Society2026

Targeted and Untargeted Urinary Metabolomic Analyses of Organophosphate Pesticides Exposure and Attention-Deficit/Hyperactivity Disorder in Children.

Hsin-Yun Tseng, Chi-Jen Lo, Boopathi Subramani, Jia-Woei Hou, Ching-Jung Yu, Ting-Yu Fang, Betau Hwang, Mei-Ling Cheng, Mei-Lien Chen

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Article in Metabolomics : Official journal of the Metabolomic Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Hsin-Yun Tseng *Institute of Environmental and Occupational Health Sciences, School of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong Street, Taipei, 112, Taiwan.
Chi-Jen Lo *Metabolomics Core Laboratory, Healthy Aging Research Center, Chang Gung University, No. 259, Wenhua 1st Road, Guishan Dist., Taoyuan, 333, Taiwan.
Boopathi SubramaniInstitute of Environmental and Occupational Health Sciences, School of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong Street, Taipei, 112, Taiwan.
Jia-Woei HouSchool of Medicine, Fu Jen Catholic University, Taipei, Taiwan.
Ching-Jung YuInstitute of Environmental and Occupational Health Sciences, School of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong Street, Taipei, 112, Taiwan.
Ting-Yu FangInstitute of Environmental and Occupational Health Sciences, School of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong Street, Taipei, 112, Taiwan.
Betau HwangDepartment of Child and Adolescent Psychiatry, Taipei City Hospital, Taipei, Taiwan.
Mei-Ling ChengMetabolomics Core Laboratory, Healthy Aging Research Center, Chang Gung University, No. 259, Wenhua 1st Road, Guishan Dist., Taoyuan, 333, Taiwan. chengm@mail.cgu.edu.tw.
Mei-Lien ChenInstitute of Environmental and Occupational Health Sciences, School of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong Street, Taipei, 112, Taiwan. mlchen@nycu.edu.tw.ORCID http://orcid.org/0000-0002-8349-0126

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionExposure to organophosphate pesticides (OPs) has been associated with increased oxidative stress and a higher risk of attention-deficit/hyperactivity disorder (ADHD). However, metabolic insights underlying ADHD and the potential pathophysiological role of OPs exposure remain limited.

objectiveThis study characterized urinary metabolomic profiles associated with ADHD and examined their associations with OPs exposure and oxidative stress.

methodsUrinary metabolites from 67 children with ADHD and 98 controls were analyzed using nuclear magnetic resonance (NMR) spectroscopy and ultra-perforamnce liquid chromatography quadrupole time-of-flight mass spectrometry analysis (UPLC-QTOF-MS). Dimethyl phosphate (DMP) and 4-hydroxy-2-nonenal-mercapturic acid (HNE-MA) were used as biomarkers of OPs exposure and oxidative stress, respectively. Children were classified into high- and low-exposure/concentration groups based on DMP or HNE-MA levels.

resultsUrinary metabolomic profiles differed significantly between children with ADHD and controls. Several metabolites also differed between children with high and low DMP or HNE-MA levels. Metabolites involved in the tricarboxylic acid cycle were significantly higher in ADHD children and positively correlated with both DMP and HNE-MA. Pathway analysis suggested alterations in energy-related and amino acid metabolic pathways. Stepwise logistic regression and receiver operating characteristic curve analysis identified an 11-compound biomarker panel with good discriminatory performance in the discovery (AUC: 0.8450) and validation (AUC: 0.8748) stages.

conclusionThis metabolomic analysis suggests that OPs exposure and oxidative stress may be associated with metabolic changes in ADHD, particularly in energy metabolism and amino acid pathways. The identified biomarker panel may help distinguish children with ADHD from controls. Larger studies with multiple exposure assessments are warranted.

Indexed as

Attention Deficit Disorder with HyperactivityMetabolomicsOrganophosphatesPesticidesBiomarkersChildFemaleHumansMagnetic Resonance SpectroscopyMaleMetabolomeOxidative StressBiomarkersOrganophosphatesPesticidesADHDMetabolic profilingNeurodevelopmentOP pesticidesOxidative stress

Identifiers

PMID42517949
PMCPMC13415479

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.