ArticleJournal of computational neuroscience2026
An astro-neural-field model with application to cortical spreading depolarization.
Article in Journal of computational neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
We present a novel astro-neural-field population model with application to migraine-related cortical spreading depolarization. The model is composed of four spatio-temporal state variables: excitatory and inhibitory membrane potentials, astrocytic potassium uptake recruitment, and extracellular potassium concentration. Extending a previous neural field model, we incorporate activity-dependent astrocytic potassium clearance via a nonlinear term coupled to astrocyte dynamics. The astrocyte transfer function, like its neural counterpart, exhibits three regimes governed by extracellular potassium, capturing its effect on clearance. This yields a more comprehensive framework, better fits experimental data, and provides new insights into the mechanisms of cortical spreading depolarization.
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