ArticleACS omega2026
Solubility-Enhanced α‑Mangostin Bilayer Films: Synergizing Mucoadhesion and Protection for Effective Aphthous Ulcer Treatment.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aphthous ulcers are prevalent and painful oral mucosal lesions that substantially compromise patient quality of life, requiring effective localized treatment. α-Mangostin, a bioactive compound from mangosteen pericarp, exhibits potent anti-inflammatory properties but suffers from poor aqueous solubility. This study developed a double-layer mucoadhesive film incorporating an α-mangostin-based solid dispersion (MPESD) to enhance solubility and provide dual-functionality: protection and therapy. Mangosteen peel extract was formulated into solid dispersions using PVP K30, significantly enhancing solubility from undetectable levels to 8.12 ± 0.04 mg/mL (1:4 ratio). The films, comprising an ethylcellulose backing layer and a gelatin-HPMC mucoadhesive layer, were fabricated via solvent casting. Mechanical testing confirmed suitable puncture strength (1.63 N/mm
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.