Evidence map›Paper›PMID 42518471›Full record

ArticleACS omega2026

1'-Sugar-Tethered Cholesterol-Modified siRNAs with Variable Linker Lengths for Carrier-Free Delivery and Enhanced RNAi Efficiency.

Yurina Shimada, Ayane Tsuchida, Shin Ando, Yuri Kakisawa, Yasuko Kohda, Aya Ogata, Elsayed M Mahmoud, Jiro Kondo, Shuichi Sakamoto, Yoshihito Ueno

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yurina ShimadaDepartment of Life Science and Chemistry, the Graduate School of Natural Science and Technology, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
Ayane TsuchidaCourse of Applied Life Science, Faculty of Applied Biological Sciences, Gifu Univer-sity, 1-1 Yanagido, Gifu 501-1193, Japan.
Shin AndoGraduate School of Science and Technology, Sophia University, Tokyo 102-8554, Japan.ORCID https://orcid.org/0009-0007-3991-7851
Yuri KakisawaCourse of Applied Life Science, Faculty of Applied Biological Sciences, Gifu Univer-sity, 1-1 Yanagido, Gifu 501-1193, Japan.
Yasuko KohdaInstitute of Microbial Chemistry (BIKAKEN) Numazu Branch, Microbial Chemistry Research Foundation, 18-24 Miyamoto, Numazu, Shizuoka 410-0301, Japan.
Aya OgataDepartment of Life Science and Chemistry, the Graduate School of Natural Science and Technology, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.ORCID https://orcid.org/0000-0002-6474-6229
Elsayed M MahmoudCourse of Applied Life Science, Faculty of Applied Biological Sciences, Gifu Univer-sity, 1-1 Yanagido, Gifu 501-1193, Japan.
Jiro KondoGraduate School of Science and Technology, Sophia University, Tokyo 102-8554, Japan.ORCID https://orcid.org/0000-0002-5682-3685
Shuichi SakamotoInstitute of Microbial Chemistry (BIKAKEN) Numazu Branch, Microbial Chemistry Research Foundation, 18-24 Miyamoto, Numazu, Shizuoka 410-0301, Japan.
Yoshihito UenoDepartment of Life Science and Chemistry, the Graduate School of Natural Science and Technology, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.ORCID https://orcid.org/0000-0003-3492-4677

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small interfering RNAs (siRNAs) hold significant therapeutic potential but require chemical modifications to achieve efficient delivery and robust RNA interference (RNAi) in target cells. Here, we report a series of newly developed cholesterol-conjugated siRNAs engineered to enable carrier-free cellular uptake and potent gene silencing. Novel 1'-sugar-linked cholesterol derivatives featuring alkyl linkers of 0, 2, 4, or 6 carbons were designed and synthesized. These derivatives (

Identifiers

PMID42518471
PMCPMC13382753

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.