ReviewFrontiers in toxicology2026
The role of mycotoxins in lipid metabolism and homeostasis: a systematic review.
Review in Frontiers in toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
Funding
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Abstract
Background: Mycotoxins are widespread food contaminants that pose a significant global health concern. While their hepatotoxic, nephrotoxic, and carcinogenic effects are well established and characterized, their effects on adipose tissue biology and systemic lipid regulation remain incompletely understood. Given adipose tissue's central role in lipid homeostasis, endocrine regulation, and as a storage reservoir for adipophilic compounds, understanding these effects is critical. Methods: This systematic review was conducted in accordance with the PRISMA 2020 guidelines, and prospectively registered to PROSPERO (CRD42022287044). A comprehensive literature search was conducted in CENTRAL, Embase, and MEDLINE (PubMed) through 16 January 2026. Experimental Results: Twenty-one experimental studies met the inclusion criteria. Across animal models, mycotoxin exposure consistently disrupted lipid homeostasis, leading to elevated serum triglyceride, cholesterol, LDL, and VLDL levels, alongside reduced HDL concentrations. These effects were mediated through toxin-specific mechanisms, including inhibition of Conclusion: Mycotoxins exert significant, toxin-specific effects on lipid metabolism and adipose tissue function and may contribute to cardiometabolic dysfunction. Adipose tissue appears to play a key role in mycotoxin bioaccumulation, with potential implications for chronic exposure and delayed systemic toxicity.
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