ArticleFrontiers in genetics2026
Remodelin treatment reshapes inflammation-related transcriptomic signatures in experimental thalamic hemorrhage.
Article in Frontiers in genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Thalamic hemorrhage is a severe subtype of intracerebral hemorrhage in which secondary neuroinflammation contributes to tissue injury and neurological deterioration. N-acetyltransferase 10 (NAT10), an RNA N4-acetylcytidine writer, has been implicated in inflammatory regulation and neurological disorders. However, inflammation-related transcriptomic changes associated with Remodelin treatment after thalamic hemorrhage remain unclear Methods: mRNA transcriptome sequencing was performed on perilesional thalamic tissues from control, thalamic hemorrhage model, and Remodelin-treated mice. Differentially expressed genes were identified for the Model versus Control and Remodelin Intervention versus Model comparisons. Genes showing opposite directions of regulation across the two comparisons were defined as Remodelin-reversed differentially expressed genes. GeneCards-derived inflammation-related genes were converted to mouse orthologs and intersected with Remodelin-reversed genes. Protein-protein interaction analysis, Gene Ontology and KEGG enrichment analyses, gene set enrichment analysis, immune-cell signature estimation, and transcription factor/miRNA regulatory network prediction were performed. Key candidates were validated by quantitative RT-PCR. Results: RNA-seq identified 499 differentially expressed genes in the Model versus Control comparison and 664 in the Remodelin Intervention versus Model comparison. Among 46 shared differentially expressed genes, 42 showed opposite-direction regulation. Ortholog-corrected screening identified 9 Remodelin-reversed inflammation-related candidates: Conclusion: This study identifies Remodelin-reversed inflammation-related transcriptomic signatures in experimental thalamic hemorrhage.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.