A pleiotropic single-molecule, sustained-release regenerative scaffold enables coordinated repair after ischemic stroke.

Li Ruan, Wenzhe Du, Huaqi Wang, Yifu Ma, Fangling Sun, Feng Tian, Zunjing Liu, Jiajia Xue

Abstract read

In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Li RuanState Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, China.

Wenzhe DuState Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, China.

Huaqi WangState Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, China.

Yifu MaDepartment of Laboratory Animal Center, Xuanwu Hospital of Capital Medical University, Beijing Municipal Geriatric Medical Research Center, Beijing, China.

Fangling SunDepartment of Laboratory Animal Center, Xuanwu Hospital of Capital Medical University, Beijing Municipal Geriatric Medical Research Center, Beijing, China.

Feng TianState Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, China.

Zunjing LiuDepartment of Neurology, Peking University People's Hospital, 11 Xizhimen South Street, Xicheng District, Beijing, China.

Jiajia XueState Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic stroke induces acute oxidative damage followed by prolonged inflammation and incomplete tissue reconstruction, creating a need for local therapies that provide sustained neuroprotection and repair support. Here, an injectable hybrid scaffold is developed that integrates a brain-compliant hydrogel with short electrospun nanofibers for sustained local delivery of morroniside (MOR), a pleiotropic small molecule with antioxidant, anti-inflammatory and pro-regenerative activities. The hydrogel provides early MOR release to mitigate acute injury, while the nanofibers enable sustained delivery together with extracellular-matrix-mimetic cues that support angiogenesis, neurogenesis, and axonal remodeling.

Indexed as

Hybrid scaffoldHydrogelsIschemic strokeMORShort electrospun fibers

Identifiers

PMID42518657

DOI10.1016/j.bioactmat.2026.07.011

PMCPMC13383311

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.