ArticleOphthalmology science2026
Plasma Proteomics Identifies Proteins and Pathways Associated with Cataract: A Prospective Cohort Study.
Article in Ophthalmology science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
14 authors.
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Abstract
Objective: To systematically identify plasma proteins associated with cataract development and explore their potential causal relationships. Design: Prospective population-based cohort study with integrated Mendelian randomization (MR) and colocalization analyses. Participants: Forty-nine thousand, five hundred and eighty-one UK Biobank participants free of cataract at baseline. Methods: Cox proportional hazards models were used to assess associations between 2920 plasma proteins and cataract risk, followed by MR to evaluate causal relationships. Colocalization analysis was conducted to examine whether identified protein-cataract associations shared causal genetic variants. Main Outcome Measures: Incident cataract. Results: Of the 2920 plasma proteins analyzed, 58 demonstrated significant associations with cataract risk ( Conclusions: This study identified distinct plasma proteomic signatures associated with incident cataract, offering novel insights into cataract pathogenesis and highlighting potential targets for early detection and therapeutic development. Financial Disclosures: The author has no/the authors have no proprietary or commercial interest in any materials discussed in this article.
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