Evidence map›Paper›PMID 42519010›Full record

ArticleiScience2026

Spermidine targets GGA-rich small RNAs for virulence regulation.

Chao Wang, Xiaoling Liu, Changqing Chang, Yu Deng, Lian-Hui Zhang, Sujoy Ghosh, Yong-Gui Gao, Kanaga Sabapathy

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chao WangSchool of Biological Sciences, Nanyang Technological University, Singapore 639798, Singapore.
Xiaoling LiuChongqing Academy of Chinese Materia Medica, Chongqing 400065, China.
Changqing ChangGuangdong Province Key Laboratory of Microbial Signals and Disease Control, Integrative Microbiology Research Centre, South China Agricultural University, Guangzhou 510642, China.
Yu DengSchool of Biological Sciences, Nanyang Technological University, Singapore 639798, Singapore.
Lian-Hui ZhangGuangdong Province Key Laboratory of Microbial Signals and Disease Control, Integrative Microbiology Research Centre, South China Agricultural University, Guangzhou 510642, China.
Sujoy GhoshPennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
Yong-Gui GaoSchool of Biological Sciences, Nanyang Technological University, Singapore 639798, Singapore.
Kanaga SabapathySchool of Biological Sciences, Nanyang Technological University, Singapore 639798, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spermidine (SPD), a polyamine essential for various biological processes, has long been recognized as a signaling molecule. Yet, its specific molecular targets and mechanisms of action remain elusive. In this study, we uncover a previously unknown mechanism whereby SPD selectively binds to small regulatory RNAs, driving their degradation and subsequently modulating virulence in

Indexed as

binding motifmRNA splicingpolyaminesPseudomonas aeruginosaRsmZspermidineT3SS

Identifiers

PMID42519010
PMCPMC13382137

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.