Evidence map›Paper›PMID 42519051›Full record

ArticleiScience2026

Ptprz1b phosphatase binds Prickle2 to promote its membrane localization.

Yao Le, Sarka Novotna, Lorena Agostini Maia, Nicholas S Tolwinski, Christoph Winkler, Jakub Harnos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yao LeDepartment of Biological Sciences and Centre for Bioimaging Sciences, National University of Singapore, Singapore 117543, Singapore.
Sarka NovotnaDepartment of Experimental Biology, Faculty of Science, Masaryk University, 62500 Brno, Czechia.
Lorena Agostini MaiaDepartment of Experimental Biology, Faculty of Science, Masaryk University, 62500 Brno, Czechia.
Nicholas S TolwinskiProgramme in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore 169857, Singapore.
Christoph WinklerDepartment of Biological Sciences and Centre for Bioimaging Sciences, National University of Singapore, Singapore 117543, Singapore.
Jakub HarnosDepartment of Experimental Biology, Faculty of Science, Masaryk University, 62500 Brno, Czechia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Wnt/planar cell polarity (PCP) pathway plays a critical role in the development and homeostasis of multicellular organisms. Molecularly, it is organized into two core protein complexes, Vangl/Prickle and Dishevelled/Frizzled. Here, we identify the receptor-type tyrosine phosphatase Ptprz1b as a regulator of Prickle membrane retention. Ptprz1b binds Prickle2 through multiple regions and depends on Vangl through formation of a membrane-competent Prickle2 pool rather than direct Ptprz1b-Vangl binding. Loss of

Indexed as

membrane localizationPlanar cell polarity signalingprotein tyrosine phosphatase receptorVangl/Prickle

Identifiers

PMID42519051
PMCPMC13382465

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.