ArticleiScience2026
A cell-free browning strategy: Exosomal miR-21a-5p from ADSCs targets PDCD4 to reshape adipose metabolism.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Adipose-derived stem cell exosomes (ADSC-EXOs) serve as cell-free therapy, transporting signaling molecules that modulate adipose plasticity. However, the precise molecular mechanisms involved remain unclear. We used a high-fat diet-induced mouse obesity model and an MDI-induced 3T3-L1 cell differentiation model. We found that ADSC-EXOs improved systemic glucose and lipid metabolism, decreased PDCD4 and white adipocyte marker expression, and increased brown adipocyte marker expression along with the activation of the LXR-α/Akt pathway in inguinal adipose tissue. miR-21a-5p mimic or siPDCD4 transfection in 3T3-L1 cells recapitulated these effects, reducing lipid accumulation and promoting adipocyte browning, whereas PDCD4 overexpression produced the opposite effects. Mechanistically, miR-21a-5p directly targeted the 3' UTR of PDCD4. These findings indicate that ADSC-EXOs facilitate white fat browning through the miR-21a-5p/PDCD4 axis and thus activate the LXR-α/Akt signaling pathway, offering a potential therapeutic strategy for obesity-related metabolic dysfunction.
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