Evidence map›Paper›PMID 42519338›Full record

ArticleFrontiers in immunology2026

Alexia A Belperron, Jialing Mao, Carmen J Booth, Linda K Bockenstedt

Abstract read
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alexia A BelperronDepartment of Internal Medicine, Section of Rheumatology, Allergy and Immunology, Yale School of Medicine, New Haven, CT, United States.
Jialing MaoDepartment of Internal Medicine, Section of Rheumatology, Allergy and Immunology, Yale School of Medicine, New Haven, CT, United States.
Carmen J BoothDepartment of Comparative Medicine, Yale School of Medicine, New Haven, CT, United States.
Linda K BockenstedtDepartment of Internal Medicine, Section of Rheumatology, Allergy and Immunology, Yale School of Medicine, New Haven, CT, United States.

Funding

Pathogenesis of Borrelia miyamotoi infection and Lyme coinfection in miceR01AI130068 · NIAID · YALE UNIVERSITY · PI BOCKENSTEDT, LINDA K. · 2018 to 2022
$2.1M
Borrelia Miyamotoi Infection in Mice and HumansR56AI114859 · NIAID · YALE UNIVERSITY · PI BARBOUR, ALAN G., BOCKENSTEDT, LINDA K. · 2015 to 2015
$670k
NIAID NIH HHS R01 AI130068NIAID NIH HHS R56 AI114859
6 · The paper itself

Abstract

Introduction: Soft tick relapsing fever (RF) infections cause adverse pregnancy outcomes, but the impact of hard tick RF on pregnancy is unknown. We assessed pregnancy outcomes in a mouse model of hard tick RF using the Methods: Litter sizes, pup survival and presence of spirochetemia were assessed in pups from immunodeficient ( Results: Outcomes of pregnancies in immunodeficient mice revealed reduced numbers of live pups delivered and/or pup survival to weaning, independent of the route of infection, in comparison with uninfected dams. With tick-transmitted infection, we assessed the number of viable fetal-placental units present at embryonic gestation day 18.5 and found higher numbers of embryonic pups than live pups delivered in a similarly infected group of dams followed to term. Spirochetes were not detected in blood or tissues from day 18.5 embryos but were found within yolk sacs and placentae. Infection in weanling mice from immunodeficient dams was rare regardless of timing or route of infection of the dams, and likely due to spirochetes transmitted during delivery, not Discussion: Our results demonstrate that

Indexed as

BorreliaPregnancy Complications, InfectiousRelapsing FeverAnimalsDisease Models, AnimalFemaleImmunocompromised HostMiceMice, KnockoutPregnancyPregnancy OutcomeBorrelia miyamotoiIxodes ticksmousepregnancyrelapsing feverspirochetes

Identifiers

PMID42519338
PMCPMC13381220

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.