Evidence map›Paper›PMID 42519346›Full record

ArticleInfection prevention in practice2026

Clonal dissemination of linezolid-resistant

Katrine Snorradottir Steen Gudmundsson, Karen Leth Nielsen, Helle Boelsmand Bak, Rasmus L Marvig, Andreas Petersen, Anna Emilie Henius, Jenny Dahl Knudsen, Frederik Boëtius Hertz

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Article in Infection prevention in practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Katrine Snorradottir Steen GudmundssonDepartment of Clinical Microbiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Karen Leth NielsenDepartment of Clinical Microbiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Helle Boelsmand BakDepartment of Clinical Microbiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Rasmus L MarvigDepartment of Clinical Biochemistry, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Andreas PetersenDepartment of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark.
Anna Emilie HeniusDepartment of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark.
Jenny Dahl KnudsenDepartment of Clinical Microbiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Frederik Boëtius HertzDepartment of Clinical Microbiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Linezolid-resistant Methods: Clinical isolates of Findings: In total, 24 patients with at least one clinical LRSE isolate were identified. WGS analysis confirmed that all isolates belonged to a single clone, exhibiting one to 50 single-nucleotide polymorphism differences over a 46-month period. EpiLinx revealed overlapping hospital admissions, facilitating direct transmission. All patients had invasive devices. The Department of Surgical Gastroenterology exhibited notably high linezolid usage than the hospital average at 144.3 DDD/month, accounting for 20% of total hospital consumption. Conclusion: The outbreak was characterized by clonal dissemination of LRSE, strongly associated with elevated linezolid usage in the Department of Surgical Gastroenterology. These findings underscore the critical impact of departmental antibiotic consumption on the emergence and spread of resistant organisms, and highlight the value of real-time genomic surveillance and digital epidemiological tools in outbreak management.

Indexed as

Antimicrobial stewardshipGenomic epidemiologyHospital-acquired infectionLinezolid resistanceMolecular clock analysisStaphylococcus epidermidis ST22

Identifiers

PMID42519346
PMCPMC13382309

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.