ArticlePain reports2026
Astrocyte store-operated calcium entry is required for centrally mediated neuropathic pain.
Article in Pain reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
- Update of
Authors and funding
2 authors.
Funding
Abstract
Introduction: Acute injuries transition to chronic neuropathic pain through central sensitization (CS), which involves plastic changes to nociceptive networks within the central nervous system. Astrocytes are essential mediators of CS, and many neuromodulatory functions of astrocytes are regulated by complex Ca Objectives: Our objective was to test the role of store-operated Ca Methods: We used a Results: Astrocytes exhibited Stim and Orai-dependent Ca Conclusion: Astrocyte SOCE is necessary and sufficient for CS and thermal allodynia in
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.