ArticleMolecular therapy. Nucleic acids2026
Evaluation of lipid nanoparticle adjuvants with different PEG lipid ratios and phospholipid modifications in non-human primates.
Article in Molecular therapy. Nucleic acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Lipid nanoparticles (LNPs) used in mRNA vaccines possess adjuvant activity, but little is known about the composition-function relationships that drive their adjuvanticity. Recent studies demonstrated that, in addition to the ionizable lipids, the type of phospholipids and the ratio of polyethylene glycol (PEG) lipids in LNPs also influence the magnitude and quality of vaccine-induced immune responses. Here we evaluated the cellular and humoral immunity elicited by LNPs with different phospholipids and PEG lipid ratios in cynomolgus macaques. We observed differences in antibody and CD4
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