Evidence map›Paper›PMID 42519572›Full record

ArticleMolecular therapy. Nucleic acids2026

Y-RNAs and their fragments reflect kidney injury in diabetic kidney disease.

Qiao Zhao, Yunyi Liang, Rudmer Postma, Jacques M G J Duijs, Juliette A de Klerk, Leen M 't Hart, Joris I Rotmans, Anton Jan van Zonneveld, Roel Bijkerk

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Article in Molecular therapy. Nucleic acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qiao ZhaoDepartment of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Yunyi LiangDepartment of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Rudmer PostmaDepartment of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Jacques M G J DuijsDepartment of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Juliette A de KlerkDepartment of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Leen M 't HartDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.
Joris I RotmansDepartment of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Anton Jan van ZonneveldDepartment of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Roel BijkerkDepartment of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic kidney disease (DKD) affects one-third of patients with diabetes mellitus (DM). Y-RNAs (RNYs) are a type of highly abundant non-coding RNA that could potentially serve as disease biomarkers. This study investigated whether circulating RNYs associate with DKD that may facilitate early detection and intervention of DKD. Patients were categorized into three groups: healthy controls (HCs), patients with type 1 DM without DKD, and those with DKD. We examined the levels of RNYs and their fragments using RT-qPCR. Levels of RNYs were determined in three main non-coding RNA carriers (extracellular vesicles [EVs], AGO2, and HDL). Serum expression of full-length RNYs mainly decreased in the DKD group, while RNY fragments were elevated in the DM group compared to the HC group and decreased in the DKD group compared to the DM group. While we observed circulating RNYs to be attached to AGO2 and HDL, the majority is present in EVs. In addition, the subtype ratio of full-length RNY3/RNY4 associated with kidney injury, while RNY1, RNY3, RNY3/RNY4 ratio and all fragment RNYs strongly associated with markers of vascular injury. Circulating RNYs and their fragments associate with (vascular injury in) DKD show potential as biomarkers for kidney injury in DM.

Indexed as

Argonaute 2biomarkercirculationdiabetic kidney diseaseextracellular vesicleshigh-density lipoproteinMT: non-coding RNAsvascular injuryY-RNA

Identifiers

PMID42519572
PMCPMC13382184

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.