Evidence map›Paper›PMID 42519633›Full record

ArticleArthroscopy techniques2026

Prolotherapy in the Treatment of Knee Osteoarthritis: How to Perform.

José L Rocha de Faria, Fabiana Alves C Menegassi, Sandra T N Minamoto, Guilherme Blois V Pereira, Fábio Henrique P Videira, Diego G Severgnine, Caio Gomes de Lima, José Paulo G Aramburu Filho, Geraldo da R Motta, João Antônio M Guimarães and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthroscopy techniques, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

José L Rocha de FariaNational Institute of Traumatology and Orthopedics of Brazil Rio de Janeiro Brazil.ORCID https://orcid.org/0000-0003-2635-1469
Fabiana Alves C MenegassiNational Institute of Traumatology and Orthopedics of Brazil Rio de Janeiro Brazil.ORCID https://orcid.org/0000-0002-6548-4590
Sandra T N MinamotoNational Institute of Traumatology and Orthopedics of Brazil Rio de Janeiro Brazil.
Guilherme Blois V PereiraNational Institute of Traumatology and Orthopedics of Brazil Rio de Janeiro Brazil.ORCID https://orcid.org/0009-0009-1085-5268
Fábio Henrique P VideiraSchool of Medicine Federal University Fluminense Niterói Rio de Janeiro Brazil.ORCID https://orcid.org/0000-0002-2300-0746
Diego G SevergnineNational Institute of Traumatology and Orthopedics of Brazil Rio de Janeiro Brazil.ORCID https://orcid.org/0009-0007-9086-3932
Caio Gomes de LimaNational Institute of Traumatology and Orthopedics of Brazil Rio de Janeiro Brazil.
José Paulo G Aramburu FilhoNational Institute of Traumatology and Orthopedics of Brazil Rio de Janeiro Brazil.
Geraldo da R MottaNational Institute of Traumatology and Orthopedics of Brazil Rio de Janeiro Brazil.ORCID https://orcid.org/0000-0002-5187-2787
João Antônio M GuimarãesNational Institute of Traumatology and Orthopedics of Brazil Rio de Janeiro Brazil.
Ronaldo José Faria C do AmaralDepartment of Pathological Anatomy School of Medicine Federal University of Rio de Janeiro Rio de Janeiro Brazil.ORCID https://orcid.org/0000-0002-2748-774X
Bianca GutfilenDepartment of Radiology School of Medicine Federal University of Rio de Janeiro Rio de Janeiro Brazil.ORCID https://orcid.org/0000-0001-8632-7474
Sergio Augusto L de SouzaDepartment of Radiology School of Medicine Federal University of Rio de Janeiro Rio de Janeiro Brazil.
Zartur José B MenegassiDepartment of Orthopedics School of Medicine Federal University of Rio de Janeiro Rio de Janeiro Brazil.ORCID https://orcid.org/0000-0002-6902-0136

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The conservative treatment of knee osteoarthritis is a challenge; since it has no cure, many patients do not want or cannot undergo surgical procedures. Among the various options, we have injectable therapies, especially the so-called "regenerative," such as the use of hyaluronic acid, orthobiologicals, and prolotherapy. In the latter, its use has increased, either due to ease of application, low cost, or good results, especially with the improvement of pain and function. This technical note describes the protocol for the preparation and injection of intra- and extra-articular prolotherapy in the treatment of knee osteoarthritis. Numerous articles show its benefit both in improving the symptomatic picture and the life quality of affected patients, as long as we follow ideal parameters of the preparation of the substance and how to apply it.

Identifiers

PMID42519633
PMCPMC13383907

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.