Four Undescribed Chromane-Type Meroterpenoids From Sargassum siliquastrum and Their Inhibitory Activity Against Amyloid-β42 Aggregation.

Mafumi Horiuchi, Joh Yamanaka, Hideyuki Shigemori, Yasuki Higashimura, Mitsuhiro Sekiguchi

Abstract read

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Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Mafumi HoriuchiGraduate School of Bioresources and Environmental Science, Ishikawa Prefectural University, Nonoichi, Ishikawa, Japan.

Joh YamanakaGraduate School of Science and Technology, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Hideyuki ShigemoriInstitute of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.ORCID https://orcid.org/0000-0001-9778-8057

Yasuki HigashimuraGraduate School of Bioresources and Environmental Science, Ishikawa Prefectural University, Nonoichi, Ishikawa, Japan.ORCID https://orcid.org/0000-0003-0540-4306

Mitsuhiro SekiguchiGraduate School of Bioresources and Environmental Science, Ishikawa Prefectural University, Nonoichi, Ishikawa, Japan.ORCID https://orcid.org/0000-0001-6780-4538

Funding

Mitani Foundation for Research and Development

6 · The paper itself

Abstract

Four undescribed chromane-type meroterpenoids, sargasilides H-K (1-4), were isolated from the brown alga Sargassum siliquastrum. Their structures were elucidated by comprehensive spectroscopic analyses, and their absolute configurations were partially established by electronic circular dichroism and the modified Mosher's method. The inhibitory effects of 1-4 against amyloid-β42 aggregation were evaluated using a thioflavin T fluorescence assay. Among them, sargasilide J (3) exhibited the strongest activity. Furthermore, compound 3 significantly delayed paralysis in a transgenic Caenorhabditis elegans model expressing amyloid-β42. These findings provide further insight into the structural features governing amyloid-β42 aggregation inhibition in chromane-type meroterpenoids.

Indexed as

Amyloid beta-PeptidesChromansPeptide FragmentsSargassumTerpenesAnimalsAnimals, Genetically ModifiedCaenorhabditis elegansProtein AggregatesAmyloid beta-Peptidesamyloid beta-protein (1-42)ChromansPeptide FragmentsProtein AggregatesTerpenesAlzheimer's diseaseamyloid‐βbrown algameroterpenoidSargassum siliquastrum

Identifiers

PMID42520110

DOI10.1002/cbdv.71550

PMCPMC13412067

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.