Evidence map›Paper›PMID 42520125›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Distinct repair processes produce APOBEC-induced deletions, tandem substitutions, and complex mutations in yeast and human cells.

Alexandra Puzon, Atri Raval, Cameron Cordero, Daniel Schiefen, Piotr A Mieczkowski, Steven A Roberts, Tony M Mertz

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Distinct repair processes produce APOBEC-induced deletions, tandem substitutions, and complex mutations in yeast and human cells.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alexandra Puzon *School of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman, WA 99164.
Atri Raval *School of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman, WA 99164.
Cameron Cordero *Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405.
Daniel SchiefenDepartment of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405.
Piotr A MieczkowskiDepartment of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599.ORCID 0000-0003-2418-0096
Steven A RobertsSchool of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman, WA 99164.ORCID 0000-0002-3628-5808
Tony M Mertz *School of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman, WA 99164.ORCID 0000-0002-9243-4062

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HONG JIN KIM · 1985 to 2026
$201.5M
Regulation of APOBEC3 cytidine deaminase-induced mutation during cancerdevelopmentR01CA269784 · NCI · WASHINGTON STATE UNIVERSITY · PI STEVEN A ROBERTS · 2023 to 2026
$2.0M
HHS | NIH | National Cancer Institute (NCI) CA269784NCI NIH HHS P30 CA016086NCI NIH HHS R01 CA269784
6 · The paper itself

Abstract

APOBEC3A (A3A) and APOBEC3B (A3B) induce single base substitution signatures SBS2 and SBS13, which are composed of C>T and C>G mutations, respectively, at T

Indexed as

Cytidine DeaminaseDNA RepairMinor Histocompatibility AntigensMutationSaccharomyces cerevisiaeCell Line, TumorHumansProteinsSequence DeletionAPOBEC3A protein, humanAPOBEC3B protein, humanCytidine DeaminaseMinor Histocompatibility AntigensProteinsAPOBECscancerDNA repairmutagenesis

Identifiers

PMID42520125
PMCPMC13438585

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.