ArticleChemistry & biodiversity2026
Chiral Coumarin Enantiomers From Prangos pabularia Roots: Absolute Configuration, Tyrosinase Activation, and Anti-Vitiligo Potential in B16F10 Cells.
Sunbula Atolikshoeva, Sodik Numonov, Jun Li, Jiangyu Zhao, Mayire Nueraihemaiti, Isomiddin Gulmurodov, Xin Xuelei, Maitinuer Maiwulanjiang, Khurshed Bozorov, Ibrohimjon Askarov and 2 more
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In one paragraphArticle in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
Sunbula AtolikshoevaKey Laboratory of Plant Resources and Chemistry in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, P. R. China.ORCID https://orcid.org/0009-0005-1139-7917 Sodik NumonovKey Laboratory of Plant Resources and Chemistry in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, P. R. China.ORCID https://orcid.org/0000-0003-4597-4047 Jun LiKey Laboratory of Plant Resources and Chemistry in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, P. R. China.ORCID https://orcid.org/0000-0002-7990-1295 Jiangyu ZhaoKey Laboratory of Plant Resources and Chemistry in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, P. R. China.ORCID https://orcid.org/0009-0004-1122-7048 Mayire NueraihemaitiKey Laboratory of Plant Resources and Chemistry in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, P. R. China.
Isomiddin GulmurodovKey Laboratory of Plant Resources and Chemistry in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, P. R. China.
Xin XueleiKey Laboratory of Plant Resources and Chemistry in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, P. R. China.ORCID https://orcid.org/0000-0001-6009-2996 Maitinuer MaiwulanjiangKey Laboratory of Plant Resources and Chemistry in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, P. R. China.ORCID https://orcid.org/0000-0003-2328-3974 Ibrohimjon AskarovDepartment of Chemistry, Andijan State University, Andijan, Uzbekistan.
Guangmin YaoKey Laboratory of Plant Resources and Chemistry in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, P. R. China.ORCID https://orcid.org/0000-0002-8893-8743 Haji Akber AisaKey Laboratory of Plant Resources and Chemistry in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, P. R. China.ORCID https://orcid.org/0000-0003-4652-6879 Funding
Central Asian Drug Discovery & Development Center of Chinese Academy of Sciences CAM 202407Chinese Academy of Sciences President's International Fellowship Initiative 2026PVB0155National Key Research and Development Program of China 2025YEE0104100Xinjiang Science and Technology Major Project 2022A03018
6 · The paper itselfAbstract
In order to isolate and characterize enantiomeric compounds from the roots of Prangos pabularia the dichloromethane extract was extensively fractionated by column chromatography, flash, semi-preparative high performance liquid chromatography (HPLC), and chiral HPLC. Six pairs of enantiomers were isolated from dichloromethane extracts using preparative chiral HPLC. The absolute configurations of the isolated isomers were identified using circular dichroism (CD). The anti-vitiligo activities of the corresponding (S)- and (R)-enantiomers were assessed by determining their tyrosinase activation rates. (S)-Pangelin 9 (PPE19-1) showed higher activity with 125.42% than (R)-pangelin 10 (PPE19-2) with 120.6%, while the positive control (8-methoxypsoralen) resulted in 122.3%. The percentage of activation rate of (S)-oxypeucidanin hydrate 1 (PPE4-1) was 119.74%, while it was 110.01% for (R) oxypeucidanin hydrate 2 (PPE4-2). We conclude that the (S, R) enantiomers of pangelin and oxypeucidanin hydrate (S, R) may be useful as pigmentation-promoting agents for the treatment of vitiligo.
Indexed as
ApiaceaeCoumarinsMonophenol MonooxygenasePlant RootsAnimalsCell Line, TumorChromatography, High Pressure LiquidEnzyme ActivationMelanogenesisMiceMolecular StructureStereoisomerismStructure-Activity RelationshipcoumarinCoumarinsMonophenol Monooxygenaseabsolute configurationB16F10 melanoma cellscircular dichroism (CD)enantiomerstyrosinase activation
Identifiers
PMID42520145
PMCPMC13412072
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