Evidence map›Paper›PMID 42520805›Full record

ArticleCell reports. Medicine2026

Parent-of-origin effects in Alzheimer's liability dissociate neurocognitive and cardiovascular traits in at-risk individuals.

Chloé Savignac, Frédéric St-Onge, Sylvia Villeneuve, AmanPreet Badhwar, Sarah A Gagliano Taliun, Sali Farhan, Maiya Geddes, Yasser Iturria Medina, Judes Poirier, R Nathan Spreng and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chloé SavignacDepartment of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, QC, Canada; Integrated Program in Neuroscience, Faculty of Medicine, McGill University, Montreal, QC, Canada; Mila - Quebec Artificial Intelligence Institute, Montreal, QC, Canada.
Frédéric St-OngeIntegrated Program in Neuroscience, Faculty of Medicine, McGill University, Montreal, QC, Canada; Research Center of the Douglas Mental Health Institute, Montreal, QC, Canada.
Sylvia VilleneuveResearch Center of the Douglas Mental Health Institute, Montreal, QC, Canada; Centre for Studies in the Prevention of Alzheimer's Disease, Douglas Mental Health Institute, McGill University, Montreal, QC, Canada; Department of Neurology and Neurosurgery, Montreal Neurological Institute (MNI), Faculty of Medicine, McGill University, Montreal, QC, Canada; McConnell Brain Imaging Centre (BIC), MNI, Faculty of Medicine, McGill University, Montreal, QC, Canada; Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, QC, Canada.
AmanPreet BadhwarDepartment of Pharmacology and Physiology & Institute of Biomedical Engineering, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada; Centre de Recherche de L'Institut Universitaire de Gériatrie de Montréal (CRIUGM), Montreal, QC, Canada.
Sarah A Gagliano TaliunDepartment of Neurosciences & Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada; Montreal Heart Institute, Montréal, QC, Canada.
Sali FarhanDepartment of Neurology and Neurosurgery, Montreal Neurological Institute (MNI), Faculty of Medicine, McGill University, Montreal, QC, Canada; Department of Human Genetics, Faculty of Medicine, McGill University, Montreal, QC, Canada.
Maiya GeddesResearch Center of the Douglas Mental Health Institute, Montreal, QC, Canada; Centre for Studies in the Prevention of Alzheimer's Disease, Douglas Mental Health Institute, McGill University, Montreal, QC, Canada; Department of Neurology and Neurosurgery, Montreal Neurological Institute (MNI), Faculty of Medicine, McGill University, Montreal, QC, Canada; Research Centre for Studies in Aging, Douglas Mental Health Institute, McGill University, Montreal, QC, Canada; McGill University Research Centre for Studies in Aging, Montreal, QC, Canada.
Yasser Iturria MedinaDepartment of Neurology and Neurosurgery, Montreal Neurological Institute (MNI), Faculty of Medicine, McGill University, Montreal, QC, Canada; McConnell Brain Imaging Centre (BIC), MNI, Faculty of Medicine, McGill University, Montreal, QC, Canada; Ludmer Centre for Neuroinformatics and Mental Health, McGill University, Montreal, QC, Canada.
Judes PoirierResearch Center of the Douglas Mental Health Institute, Montreal, QC, Canada; Centre for Studies in the Prevention of Alzheimer's Disease, Douglas Mental Health Institute, McGill University, Montreal, QC, Canada; Department of Neurology and Neurosurgery, Montreal Neurological Institute (MNI), Faculty of Medicine, McGill University, Montreal, QC, Canada; Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, QC, Canada.
R Nathan SprengResearch Center of the Douglas Mental Health Institute, Montreal, QC, Canada; Centre for Studies in the Prevention of Alzheimer's Disease, Douglas Mental Health Institute, McGill University, Montreal, QC, Canada; Department of Neurology and Neurosurgery, Montreal Neurological Institute (MNI), Faculty of Medicine, McGill University, Montreal, QC, Canada; McConnell Brain Imaging Centre (BIC), MNI, Faculty of Medicine, McGill University, Montreal, QC, Canada; Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, QC, Canada; Department of Psychology, Faculty of Medicine, McGill University, Montreal, QC, Canada.
Danilo BzdokDepartment of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, QC, Canada; Mila - Quebec Artificial Intelligence Institute, Montreal, QC, Canada; McConnell Brain Imaging Centre (BIC), MNI, Faculty of Medicine, McGill University, Montreal, QC, Canada; School of Computer Science, McGill University, Montreal, QC, Canada. Electronic address: danilo.bzdok@mcgill.ca.
PREVENT-AD Research Group

Funding

Investigating the impact of loneliness on brain aging and pre-symptomatic Alzheimer's disease progressionR01AG068563 · NIA · MCGILL UNIVERSITY · PI BZDOK, DANILO, SPRENG, ROBERT NATHAN · 2020 to 2024
$2.3M
Application of a Bayesian strategy to ABCD: Identification of substance use risk and COVID-19 effects on neurodevelopmentR01DA053301 · NIDA · YALE UNIVERSITY · PI Sarah Yip · 2022 to 2026
$1.6M
NIA NIH HHS R01 AG068563NIDA NIH HHS R01 DA053301
6 · The paper itself

Abstract

Alzheimer's disease (AD) has a higher prevalence in women than men and is more frequently inherited from mothers than fathers. Yet, while neuroimaging and biomarker studies link maternal family history to stronger AD-related alterations, epidemiological studies suggest that paternal history confers comparable or even greater risk. Here, we leverage the deeply profiled PREVENT-AD cohort to derive three intermediate phenotypes of AD susceptibility. Drawing on nearly 1,000 individual study visits, we quantify how these intermediate phenotypes vary as a function of maternal versus paternal AD lineage. We show that lineage-specific differentiation, including both maternal and paternal biases, is reflected in the brain structure and phenome of adult children of AD patients. Cognitive and cardiovascular risk markers, together with associated genetic variants, show the strongest differentiation along the parental-lineage spectrum of disease susceptibility relative to other correlates of AD burden. Our cross-generational analysis ultimately delineates multidimensional parent-of-origin effects in AD genealogy.

Indexed as

Alzheimer DiseaseCardiovascular DiseasesGenetic Predisposition to DiseaseAgedCognitionFemaleHumansMaleParentsPhenotypeRisk FactorsAlzheimer’s diseasefamily risklineageparent-of-origin effectsphenomicsPREVENT-AD

Identifiers

PMID42520805
PMCPMC13522784

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.