Evidence map›Paper›PMID 42521707›Full record

ArticleScientific reports2026

Deficiency of the aryl hydrocarbon receptor in kidney epithelial cells does not influence the development of atherosclerosis.

Rosanna Huchzermeier, Caron Romel, Kathrin Abschlag, Manuel Rogg, Christoph Schell, Emiel P C van der Vorst

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rosanna HuchzermeierDepartment of Internal Medicine I, Aachen-Maastricht Institute for Cardio-Renal Disease (AMICARE), Institute for Molecular Cardiovascular Research (IMCAR), University Hospital Aachen, RWTH Aachen University, Aachen, Germany.
Caron RomelDepartment of Internal Medicine I, Aachen-Maastricht Institute for Cardio-Renal Disease (AMICARE), Institute for Molecular Cardiovascular Research (IMCAR), University Hospital Aachen, RWTH Aachen University, Aachen, Germany.
Kathrin AbschlagDepartment of Internal Medicine I, Aachen-Maastricht Institute for Cardio-Renal Disease (AMICARE), Institute for Molecular Cardiovascular Research (IMCAR), University Hospital Aachen, RWTH Aachen University, Aachen, Germany.
Manuel RoggInstitute of Surgical Pathology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
Christoph SchellInstitute of Surgical Pathology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
Emiel P C van der VorstDepartment of Internal Medicine I, Aachen-Maastricht Institute for Cardio-Renal Disease (AMICARE), Institute for Molecular Cardiovascular Research (IMCAR), University Hospital Aachen, RWTH Aachen University, Aachen, Germany. evandervorst@ukaachen.de.ORCID http://orcid.org/0000-0001-5771-6278

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aryl hydrocarbon receptor (AHR) is recognised as an important mediator of inflammatory processes, including those in kidney health. Patients suffering from kidney diseases have an increased risk of cardiovascular diseases, such as atherosclerosis. Since the AHR can be activated in the kidney by, e.g., tryptophan metabolites and contribute to inflammatory processes, we hypothesized that a deficiency of the Ahr in the kidney epithelium in mice fed a high-fat diet could impact the development of atherosclerosis by altering renal function. We analysed Apoe

Indexed as

AtherosclerosisBasic Helix-Loop-Helix ProteinsEpithelial CellsKidneyReceptors, Aryl HydrocarbonAnimalsApolipoproteins EDiet, High-FatInflammationMaleMiceMice, KnockoutAhr protein, mouseApolipoproteins EBasic Helix-Loop-Helix ProteinsReceptors, Aryl HydrocarbonAryl hydrocarbon receptorAtherosclerosisKidney epithelial cells

Identifiers

PMID42521707
PMCPMC13416111

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.