Evidence map›Paper›PMID 42522069›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Associations of dementia polyexposure scores to Alzheimer's disease endophenotypes in a diverse population.

Meri Okorie, Xiaqing Jiang, Kristine Yaffe, Jennifer S Yokoyama, Shea J Andrews, Health and Aging Brain Study–Health Disparities

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Meri OkorieEdward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, California, USA.ORCID https://orcid.org/0000-0002-0487-3031
Xiaqing JiangDepartment of Psychiatry and Behavioural Sciences, University of California, San Francisco, San Francisco, California, USA.
Kristine YaffeEdward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, California, USA.
Jennifer S YokoyamaEdward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, California, USA.ORCID https://orcid.org/0000-0001-7274-2634
Shea J AndrewsEdward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, California, USA.ORCID https://orcid.org/0000-0002-1921-9470
Health and Aging Brain Study–Health Disparities

Funding

Project 2: Biomarker Analysis, Non-Genetic Risk Factors, and Their Genetic InteractionsU19AG079774 · NIA · UNIVERSITY OF PENNSYLVANIA · 2023 to 2025
$24.5M
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · 2002 to 2025
$22.8M
Research Education ComponentP30AG062422 · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2025 to 2025
$4.7M
Tau Metabolism in FTD: From Gene Mutations to Molecular Chaperones and Lysosomal ProteasesU54NS123985 · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2025 to 2025
$1.8M
US-South American Initiative for Genetic-Neural-Behavioral Interactions in Human Neurodegenerative ResearchR01AG057234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Nilton Custodio, Agustin M. Ibanez · 2023 to 2023
$513k
Alzheimer's AssociationFrench FoundationGenentechGlobal Brain Health InstituteMary Oakley FoundationNational Alzheimer's Coordinating Center U24AG072122NIA NIH HHS P01AG019724NIA NIH HHS P30AG062422NIA NIH HHS R01AG057234NIA NIH HHS U19AG079774NINDS NIH HHS U54NS123985Rainwater Charitable Foundation
6 · The paper itself

Abstract

introductionDementia clinical risk scores (CRSs) provide accessible tools for identifying individuals at risk for Alzheimer's disease (AD) and related dementias, yet their performance across diverse populations and relationships to AD endophenotypes remains unclear.

methodsWe evaluated four CRSs, modified Cardiovascular Risk Factors, Aging, and Incidence of Dementia (mCAIDE), Washington Heights-Inwood Columbia Aging Project (WHICAP), Lifestyle for Brain Health (LIBRA), and Cognitive Dementia Risk (CogDRisk), in relation to cognitive impairment (CI) and AD endophenotypes, including tau phosphorylated at threonine 217 (pTau

resultsCogDRisk showed the strongest and most consistent performance across endophenotypes, pTau

conclusionsCRSs capture AD-related risk across diverse populations and modestly reflect underlying biological endophenotypes, supporting their utility in community-based risk assessment.

Indexed as

Alzheimer DiseaseDementiaEndophenotypesAgedAged, 80 and overAmyloid beta-PeptidesFemaleHumansMalePeptide FragmentsPositron-Emission TomographyRisk Factorstau ProteinsAmyloid beta-Peptidesamyloid beta-protein (1-42)Peptide Fragmentstau ProteinsAlzheimer's diseasebiomarkersclinical risk scorehealth disparitiesmodifiable risk factors

Identifiers

PMID42522069
PMCPMC13415752

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.