ReviewMolecular oncology2026
Cancer cell-intrinsic type 1 interferon: production, signaling, and outcomes within sex-biased, female malignancies.
Review in Molecular oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
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Abstract
Type 1 interferons (IFN-1), such as IFN-α and IFN-β, are the most well-studied interferon class due to their abundant expression, widespread signaling, and potent immunomodulatory functions. Although the role of these cytokines in mediating antiviral defense responses and immune activation has been well-studied, recent studies have suggested they play a more nuanced role in directing cell-autonomous responses in cancer. The role of cancer cell-autonomous IFN-1 production and signaling is complex and context dependent. IFN-1 has been shown to participate in both tumor-suppressing and -promoting activities based on the intensity and duration of the IFN-1 signal received. The cell-intrinsic roles appear to be immune-independent, mediating cancer cell responses to traditional therapies and regulating tumor progression. This review aimed to summarize the various roles of IFN-1 in cancer, with a focus on female-related malignancies-including ovarian, breast, cervical, and endometrial cancers-emphasizing the molecular mechanisms surrounding IFN-1 production and signaling, downstream functional outcomes, and therapeutic implications essential to understanding the pro- and antitumor roles of IFN-1.
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