In one paragraphReview in The Journal of experimental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
10 authors.
Nichlas M EngelsDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ 85721, USA.ORCID 0000-0003-0613-0925 Christopher T NguyenCardiovascular Innovation Research Center, Heart Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH 44196, USA.
Stephan LangeDepartment of Biomedicine, Aarhus University, DK-8000 Aarhus C, Denmark.
Matthew A CaporizzoDepartment of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA.
Lin YangNational Synchrotron Light Source II, Brookhaven National Laboratory, Upton, NY 11973-5000, USA.ORCID 0000-0003-1057-9194 Funding
X-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Vivian Stojanoff · 2019 to 2026
$38.6MVermont Center for Cardiovascular and Brain HealthP20GM135007 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Diego Adrianzen Herrera · 2020 to 2026
$17.4MRole of Myosin Binding Protein-C in the Regulation of Myocardial ContractionR01HL080367 · NHLBI · UNIVERSITY OF WASHINGTON · PI Samantha P Harris · 2005 to 2026
$7.5MModeling, measurement and prediction of cardiac magneto-stimulation thresholdsR01EB033853 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Bastien Guerin, Christopher T Nguyen · 2023 to 2026
$2.4MThe role of obscurin and Obsl1 as key determinants for diastolic functionR01HL152251 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHO, YOSHITAKE, LANGE, STEPHAN · 2021 to 2024
$2.3MCardiac microtubules as regulators of diastolic function.R01HL171614 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Matthew Caporizzo · 2024 to 2026
$1.6MA Simultaneous SAXS/WAXS Detector System for Solving Biological StructuresS10OD012331 · OD · STATE UNIVERSITY NEW YORK STONY BROOK · PI ALLAIRE, MARC · 2012 to 2012
$1.1MStructure and function of myosin binding protein-C in skeletal musclesR01AR083970 · NIAMS · UNIVERSITY OF ARIZONA · PI Samantha P Harris · 2025 to 2026
$929kExpanding synchrotron applications in biomedical research: Myocardial and skeletal muscle imaging at Brookhaven National LabsR43GM156170 · NIGMS · ACCELERATED MUSCLE BIOTECHNOLOGIES CONSULTANTS, L.L.C. · PI HARRIS, SAMANTHA P, HESSEL, ANTHONY LAWRENCE CAPOZZI · 2024 to 2024
$311kBrookhaven National LaboratoryDanmarks Frie Forskningsfond 3165-00028BDeutsche Forschungsgemeinschaft 454867250Lundbeck Foundation R396-2022-189NHLBI NIH HHS R01HL080367NIAMS NIH HHS R01AR083970NIGMS NIH HHS P30GM133893NIGMS NIH HHS R43GM156170NIGMS NIH HHS S10 OD012331NIH HHS 1R01AR083970NIH HHS 1R43GM156170NIH HHS 5R01HL080367NIH HHS P20GM135007NIH HHS P30GM133893NIH HHS R01EB033853NIH HHS R01HL152251NIH HHS R01HL171614NIH HHS S10 OD012331Novo Nordisk Fonden CAPTURE HFpEFOffice of ScienceU.S. Department of Energy DE-SC0012704U.S. Department of Energy KP1607011
6 · The paper itselfAbstract
We report on recent methodological advances at the Life Science X-ray Scattering (LiX) beamline of the National Synchrotron Light Source II (NSLS-II) to support small-angle X-ray scattering experiments on striated muscles. These experiments measure sarcomeric protein organization in healthy and diseased muscle and provide direct molecular evidence for these proteins' functional roles and dynamics. Many recent advances in sarcomeric protein research have relied on diffraction data; for example, structural and functional roles of cMyBP-C and titin, and conformational/energetic states of actomyosin cross-bridges. LiX operations are optimized for high-throughput muscle diffraction with rapid turnover and semi-automated data processing. These operations have been tested on skeletal and cardiac tissues sourced from both humans and animal models including pig, rat, mouse and zebrafish. LiX's new capacity for muscle experimentation and support for new beamline users will accelerate the investigation of sarcomeric protein structure and function, muscle biomechanics and skeletal and cardiac myopathies.
Indexed as
Muscle, SkeletalScattering, Small AngleSynchrotronsX-Ray DiffractionAnimalsHumansMiceMuscle ProteinsRatsSarcomeresMuscle ProteinsActinCardiac tissueLatticeMyosinSarcomeric protein structureSkeletal tissueSynchrotronX-ray scattering
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