Trial reportAnnals of medicine2026
Short-term efficacy and safety of 5MHz fractional microneedle radiofrequency for facial rejuvenation: a prospective study.
Trial report in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFacial aging is a multifactorial process driven by both intrinsic senescence and extrinsic environmental factors. Although fractional microneedle radiofrequency (FMR) is widely used for facial rejuvenation, clinical evidence on 5 MHz FMR remains limited. This prospective study evaluated the efficacy and safety of 5 MHz FMR.
methodsTwenty participants with facial aging underwent a single full-face 5 MHz FMR treatment. Assessments were performed at baseline and on days 1, 4, 7, 14, and 28 using the MC750 and VISIA systems. Primary outcomes included skin physiological parameters, VISIA absolute parameters, and physician global assessment (PGA). Secondary outcomes included adverse events and patient satisfaction.
resultsSkin hydration showed a transient early decline followed by gradual recovery, whereas melanin remained stable and hemoglobin exhibited a brief early increase before returning toward baseline. Skin elasticity improved significantly at V2 and remained elevated at V5-V6. VISIA analysis demonstrated transient early increases in most parameters, whereas wrinkle scores showed sustained improvement during follow-up. Greater baseline wrinkle severity was associated with greater wrinkle improvement, while subgroup analyses showed no significant differences across Fitzpatrick skin types or age groups. PGA scores progressively improved throughout follow-up. Treatment was well tolerated, with only transient erythema and burning sensations. No serious adverse events, including post-inflammatory hyperpigmentation, were observed, and 85% of participants reported being satisfied or very satisfied.
conclusionsThis prospective study provides preliminary evidence that 5 MHz FMR may offer safe and effective short-term improvement in facial aging-related features, particularly wrinkles and skin elasticity. The treatment was associated with rapid recovery, limited irritation, and a low incidence of pigment-related adverse events.
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