Evidence map›Paper›PMID 42522776›Full record

ArticleMicrocirculation (New York, N.Y. : 1994)2026

Plantar Foot Microvascular Reactivity and Oxygenation in Type 2 Diabetes and Peripheral Artery Disease: An Exploratory Study.

Josi Gallo, Allison Miller, Emily Chan, Grace Chen, Luke Benner, Erik Sillaste, Brhandom Brisueno Lopez, Carolyn Bakx, Bohyun Ro, Juan Orsi and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microcirculation (New York, N.Y. : 1994), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Josi GalloJohn Martinson Honors College, Purdue University, West Lafayette, Indiana, USA.
Allison MillerJohn Martinson Honors College, Purdue University, West Lafayette, Indiana, USA.
Emily ChanJohn Martinson Honors College, Purdue University, West Lafayette, Indiana, USA.
Grace ChenJohn Martinson Honors College, Purdue University, West Lafayette, Indiana, USA.
Luke BennerJohn Martinson Honors College, Purdue University, West Lafayette, Indiana, USA.
Erik SillasteJohn Martinson Honors College, Purdue University, West Lafayette, Indiana, USA.
Brhandom Brisueno LopezDepartment of Health and Kinesiology, Purdue University, West Lafayette, Indiana, USA.
Carolyn BakxIndiana University School of Medicine West Lafayette, West Lafayette, Indiana, USA.
Bohyun RoDepartment of Health and Kinesiology, Purdue University, West Lafayette, Indiana, USA.
Juan OrsiDepartment of Health and Kinesiology, Purdue University, West Lafayette, Indiana, USA.
Lara Soares de AraujoDepartment of Health and Kinesiology, Purdue University, West Lafayette, Indiana, USA.ORCID https://orcid.org/0000-0003-0452-2685
Ernesto RamirezDepartment of Health and Kinesiology, Purdue University, West Lafayette, Indiana, USA.
Eloisa Herrera OspinaDepartment of Health and Kinesiology, Purdue University, West Lafayette, Indiana, USA.
Qifan SongDepartment of Statistics, Purdue University, West Lafayette, Indiana, USA.
Daniel M HiraiDepartment of Health and Kinesiology, Purdue University, West Lafayette, Indiana, USA.
Igor A FernandesDepartment of Health and Kinesiology, Purdue University, West Lafayette, Indiana, USA.
Bruno T RoseguiniDepartment of Health and Kinesiology, Purdue University, West Lafayette, Indiana, USA.

Funding

NIA NIH HHS R01 AG073634-01A1The John Martinson Honors College's Research Breakthrough Award
6 · The paper itself

Abstract

objectiveMicrovascular dysfunction contributes to foot complications in type 2 diabetes (T2D) and peripheral artery disease (PAD), yet has been characterized primarily in non-plantar regions. We evaluated microvascular reactivity and oxygenation at ulcer-prone plantar sites and responses to combined heat therapy and intermittent pneumatic compression (HT + IPC).

methodsForty adults ≥ 50 years (Control n = 20, T2D n = 11, PAD with or without T2D n = 9) were studied. Plantar hallux CVC (laser Doppler flux/MAP) and forefoot StO

resultsAt the plantar hallux, the increase in %CVCmax from baseline to the initial peak was attenuated in PAD compared with controls and T2D (p < 0.01), whereas plateau responses were similar. At the forefoot, PAD showed faster deoxygenation during ischemia and slower reoxygenation during reactive hyperemia (p < 0.01). During HT + IPC, popliteal blood flow increased similarly across groups; however, plantar StO

conclusionsThese preliminary findings indicate impaired plantar microvascular function in a heterogeneous PAD cohort, most of whom also had T2D. Larger studies are needed to confirm these findings and to elucidate the underlying mechanisms.

Indexed as

Diabetes Mellitus, Type 2Diabetic FootFootMicrocirculationOxygenPeripheral Arterial DiseaseAgedFemaleHumansHyperemiaMaleMiddle AgedOxygenheat therapyperipheral artery diseaseplantar microcirculationtype 2 diabetes

Identifiers

PMID42522776
PMCPMC13417502

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.