ArticleScandinavian journal of medicine & science in sports2026
Altered Skeletal Muscle Phosphate Metabolism After Muscle Damage Is Associated With Elevated Effort Perception During Exercise in Humans.
Article in Scandinavian journal of medicine & science in sports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
It remains unclear why exercising damaged muscles is perceived as disproportionately more effortful. Given the known role of inorganic phosphate (Pi) in fatigue and afferent sensory signaling, we tested whether muscle damage disrupts phosphate metabolism and whether this is associated with heightened ratings of perceived exertion (RPE). Eighteen adults (23 ± 4 years) completed assessments before and 48 h after muscle damage induced by unilateral eccentric knee extensions (EIMD); the contralateral leg served as control. Magnetic resonance imaging quantified quadriceps cross-sectional area (Qcsa) and
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