Evidence map›Paper›PMID 42523106›Full record

ArticlemSystems2026

The associations of human genetic variations with airway microbiome, environmental exposures, and respiratory health.

Shifen Xu, Lei Yang, Jingyuan Gao, Yunfeng Shi, Xin Tang, Hanqin Cai, Liling Yang, Yuanyuan Han, Lifeng Lin, Ruilin Meng and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSystems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Shifen Xu *Guangdong Engineering Research Center of Precision Detection and Modulation of Human Microbiome, School of Life Sciences, South China Normal University, Guangzhou, Guangdong, China.ORCID 0000-0002-7674-1943
Lei Yang *Guangdong Engineering Research Center of Precision Detection and Modulation of Human Microbiome, School of Life Sciences, South China Normal University, Guangzhou, Guangdong, China.
Jingyuan Gao *Guangdong Engineering Research Center of Precision Detection and Modulation of Human Microbiome, School of Life Sciences, South China Normal University, Guangzhou, Guangdong, China.
Yunfeng Shi *Guangdong Engineering Research Center of Precision Detection and Modulation of Human Microbiome, School of Life Sciences, South China Normal University, Guangzhou, Guangdong, China.
Xin Tang *Guangdong Engineering Research Center of Precision Detection and Modulation of Human Microbiome, School of Life Sciences, South China Normal University, Guangzhou, Guangdong, China.
Hanqin CaiGuangdong Engineering Research Center of Precision Detection and Modulation of Human Microbiome, School of Life Sciences, South China Normal University, Guangzhou, Guangdong, China.
Liling YangGuangdong Engineering Research Center of Precision Detection and Modulation of Human Microbiome, School of Life Sciences, South China Normal University, Guangzhou, Guangdong, China.
Yuanyuan HanGuangdong Engineering Research Center of Precision Detection and Modulation of Human Microbiome, School of Life Sciences, South China Normal University, Guangzhou, Guangdong, China.
Lifeng LinGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, Guangdong, China.
Ruilin MengGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, Guangdong, China.
Jiufeng SunGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, Guangdong, China.ORCID 0000-0003-1047-929X
Wei-Jie GuanState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute for Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Tao TangPulmonary and Critical Care Medicine Department, Huizhou Central People's Hospital, Huizhou, Guangdong, China.
Wensheng ShuGuangdong Engineering Research Center of Precision Detection and Modulation of Human Microbiome, School of Life Sciences, South China Normal University, Guangzhou, Guangdong, China.
Chao CaoDepartment of Respiratory and Critical Medicine, Key Laboratory of Respiratory Disease of Ningbo, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.ORCID 0000-0003-0429-7617
Xue-Yan ZhengGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, Guangdong, China.ORCID 0000-0002-5251-5001
Zhang WangGuangdong Engineering Research Center of Precision Detection and Modulation of Human Microbiome, School of Life Sciences, South China Normal University, Guangzhou, Guangdong, China.ORCID 0000-0003-1278-8950
Xinzhu YiGuangdong Engineering Research Center of Precision Detection and Modulation of Human Microbiome, School of Life Sciences, South China Normal University, Guangzhou, Guangdong, China.ORCID 0000-0002-8576-0812

Funding

GuangDong Basic and Applied Basic Research Foundation 2023A1515012367, 2023A1515012328Guangdong Special Support Program 0820250237Major Project of Guangzhou National Laboratory GZNL2023A02001National Key Research and Development Program of China 2022YFA1304300National Natural Science Foundation of China 82495200, 82495201, 32170109, 32470094, 82404335, 32400372Noncommunicable Chronic Diseases-National Science and Technology Major Project 2024ZD0528400, 2025ZD0549003Open Project of Sate Key Laboratory of Respiratory Disease SKLRD-OP-202507
6 · The paper itself

Abstract

The intricate interactions between environmental exposures, the respiratory microbiome, and host genetic variations remain inadequately understood in the context of respiratory health. This study utilized sputum metagenomic data from 1,651 individuals in our previous cohort to elucidate these associations. Mendelian randomization indicated that air pollutants (e.g., SO IMPORTANCE: This study reveals why individuals exposed to identical air pollution exhibit varying degrees of respiratory severity, pointing to a critical missing link: our genetics. While pollution is a known disease trigger, our findings demonstrate that host genetic variation actively regulates and shapes the respiratory microbiome under environmental stress. By mapping specific genetic loci to pollutant-driven bacterial shifts, this work elucidates how host genetics filters environmental risks to govern microbial homeostasis. These results underscore the necessity of incorporating host-microbiome genetic regulation into environmental health research. Ultimately, this study shifts the paradigm toward personalized medicine, enabling the early identification of at-risk individuals and the development of targeted, microbiome-informed interventions.

Indexed as

Environmental ExposureGenetic VariationMicrobiotaRespiratory SystemAir PollutantsFemaleHumansMaleMiddle AgedPolymorphism, Single NucleotidePulmonary Disease, Chronic ObstructiveSputumAir Pollutantsair pollutionhost genetic variationMendelian randomizationrespiratory microbiome

Identifiers

PMID42523106
PMCPMC13483325

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.