Evidence map›Paper›PMID 42523314›Full record

ArticlebioRxiv : the preprint server for biology2026

A Quartet of Native Orai Channel Isoforms Orchestrates Graded NFAT Activation and Transcription.

Ahmed Emam Abdelnaby, Yin-Hu Wang, J Cory Benson, Isagani Perez, Mark Shen, Maxwell McDermott, Miki Jishage, Amal T Elhaw, Silvia Cruz-Rangel, Raphael Courjaret and 13 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Ahmed Emam AbdelnabyUniversity of Pittsburgh, Department of Pharmacology and Chemical Biology, Pittsburgh, PA, USA.
Yin-Hu WangDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
J Cory BensonUniversity of Pittsburgh, Department of Pharmacology and Chemical Biology, Pittsburgh, PA, USA.
Isagani PerezDepartment of Medicine, New York University Grossman School of Medicine, New York, NY, USA.
Mark ShenDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Maxwell McDermottDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Miki JishageDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Amal T ElhawUPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Silvia Cruz-RangelUniversity of Pittsburgh, Department of Pharmacology and Chemical Biology, Pittsburgh, PA, USA.
Raphael CourjaretCalcium Signaling Group, Research Department, Weill Cornell Medicine Qatar, Education City, Qatar Foundation, Doha 24144, Qatar; and Department of Systems and Computational Biomedicine, Weill Cornell Medicine, New York, USA.
Abdelaziz BelkadiCalcium Signaling Group, Research Department, Weill Cornell Medicine Qatar, Education City, Qatar Foundation, Doha 24144, Qatar; and Department of Systems and Computational Biomedicine, Weill Cornell Medicine, New York, USA.
Fang YuCalcium Signaling Group, Research Department, Weill Cornell Medicine Qatar, Education City, Qatar Foundation, Doha 24144, Qatar; and Department of Systems and Computational Biomedicine, Weill Cornell Medicine, New York, USA.
Douglas S PradoDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Shuai YuanUniversity of Pittsburgh, Department of Pharmacology and Chemical Biology, Pittsburgh, PA, USA.
Ping XinUniversity of Pittsburgh, Department of Pharmacology and Chemical Biology, Pittsburgh, PA, USA.
Adam C StraubUniversity of Pittsburgh, Department of Pharmacology and Chemical Biology, Pittsburgh, PA, USA.
Francisco F SchopferUniversity of Pittsburgh, Department of Pharmacology and Chemical Biology, Pittsburgh, PA, USA.
Nadine HempelUPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0002-5574-8783
William F HawseDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-8371-3345
David B BeckDepartment of Medicine, New York University Grossman School of Medicine, New York, NY, USA.
Khaled MachacaCalcium Signaling Group, Research Department, Weill Cornell Medicine Qatar, Education City, Qatar Foundation, Doha 24144, Qatar; and Department of Systems and Computational Biomedicine, Weill Cornell Medicine, New York, USA.ORCID 0000-0001-6215-2411
Stefan FeskeDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0000-0001-5431-8178
Mohamed TrebakUniversity of Pittsburgh, Department of Pharmacology and Chemical Biology, Pittsburgh, PA, USA.ORCID 0000-0001-6759-864X

Funding

Ca2+ Signaling Networks in Health and DiseaseR35HL150778 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TREBAK, MOHAMED · 2020 to 2025
$5.4M
Basic and Translational Studies in Redox Regulation of Cardiovascular Physiology and DiseaseR35HL161177 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Adam Carl Straub · 2022 to 2026
$4.7M
Ion channels regulating plasma cell differentiation and humoral immunityR01AI175276 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI STEFAN FESKE · 2024 to 2026
$2.0M
ATP1B3: novel regulator of T cell-mediated immunityR01AI180128 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI STEFAN FESKE · 2024 to 2026
$1.9M
NHLBI NIH HHS R35 HL150778NHLBI NIH HHS R35 HL161177NIAID NIH HHS R01 AI175276NIAID NIH HHS R01 AI180128
6 · The paper itself

Abstract

The Ca

Indexed as

calcium signalingchannelopathyCRAC channelsimmune functionNFATOrai isoforms

Identifiers

PMID42523314
PMCPMC13404903

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.