ArticlebioRxiv : the preprint server for biology2026
Kinetochore-microtubule attachments are strengthened by Cnn1 stabilization of Stu2.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Accurate chromosome segregation requires kinetochores to form robust, load-bearing attachments to dynamic spindle microtubules, mediated primarily by the Ndc80 complex. Two receptors, Dsn1 and Cnn1 (CENP-T), recruit multiple copies of Ndc80c to the kinetochore, but whether they confer functional differences to Ndc80 behavior is unclear. We previously demonstrated that kinetochore components co-purifying with the yeast Dsn1 protein can maintain persistent load-bearing attachments that track with microtubule tip growth and shortening. Using an optical trapping-based assay, we show that Cnn1 purifications also sustain dynamic microtubule attachments under load. Mutation of a conserved region within the disordered N-terminal tail of Cnn1 weakened attachment strength
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