Evidence map›Paper›PMID 42523454›Full record

ArticleResearch square2026

Integrated Myocardial and Plasma Lipidome Across the Human Obesity-Heart Failure Spectrum.

David J Polhemus, Annie Butt, Craig Resch, Kathryn Tsai, Vatsa A Batra, Shuyi Yan, Atharva Mulay, Cinthia Drachenberg, Flora Sam, Traci T Goodchild and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

David J PolhemusDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Annie ButtDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Craig ReschCardiovascular Lipidomics Laboratory, St. Boniface Hospital, Albrechtsen Research Centre, Manitoba, Canada.
Kathryn TsaiDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Vatsa A BatraDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0009-0007-1101-1345
Shuyi YanDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0009-0008-3657-7430
Atharva MulayDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Cinthia DrachenbergDepartment of Pathology, University of Maryland, Baltimore, MD, USA.ORCID 0000-0002-3104-5661
Flora SamWhitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA.
Traci T GoodchildDepartment of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA.ORCID 0009-0009-7377-780X
David J LeferDepartment of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA.
Mariam MeddebDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kenneth B MarguliesCardiovascular Institute, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-8093-4465
Kenneth C BediCardiovascular Institute, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-3588-9324
Kavita SharmaDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Navid KoleiniDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Amir RavandiCardiovascular Lipidomics Laboratory, St. Boniface Hospital, Albrechtsen Research Centre, Manitoba, Canada.ORCID 0000-0001-6663-1225
David A KassDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-1596-2299

Funding

PATHOPHYSIOLOGY OF MYOCARDIAL DISEASEST32HL007227 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Chulan Kwon, WENDY S POST · 1985 to 2026
$21.2M
Leveraging Protein Kinase G-1 Nanodomain Control and Molecular Targeting to Enhance its Therapeutic Use Against Myocardial DiseaseR35HL135827 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KASS, DAVID ALAN · 2017 to 2023
$6.3M
Intersection of Obesity and Heart Failure with Preserved Ejection FractionR35HL166565 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI David Alan Kass · 2023 to 2026
$4.1M
Epigenetic Regulation of Heart Failure with Preserved Ejection FractionR01HL174996 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DAVID JOSEPH LEFER, Thomas M. Vondriska · 2025 to 2026
$1.4M
Reduced hypusination of EIF5A impairs free ubiquitin generation resulting in the development of HFpEFK99HL179380 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Navid Koleini · 2025 to 2026
$253k
NHLBI NIH HHS K99 HL179380NHLBI NIH HHS R01 HL174996NHLBI NIH HHS R35 HL135827NHLBI NIH HHS R35 HL166565NHLBI NIH HHS T32 HL007227
6 · The paper itself

Abstract

Heart failure with preserved ejection fraction (HFpEF) has become the dominant heart failure phenotype, with many patients impacted by marked obesity. Lipid dyshomeostasis is thought to contribute, but human myocardial lipidomic data remain lacking. We performed untargeted lipidomics (>1,000 species) of ventricular samples for non-failing (NF) controls (n=40), HFpEF (n=29), and HFrEF (n=13) patients, integrating results with myocardial transcriptomics, ultrastructure, and plasma lipidomics, across a broad obesity spectrum. Multiple lipid classes increased in HFpEF myocardium including phospholipids, sphingolipids, neutral lipids, and free fatty acids, but acylcarnitines declined. HFrEF had far fewer lipid changes, and cardiolipin and phosphatidylethanolamine depletion. Lipids were minimally altered in NF hearts from obese individuals. Plasma lipidomics identified few inter-group disparities. Heart lipidomics from major animal HFpEF models (high fat diet+L-NAME, ZSF-1 rat, obese-DOCA-salt pig) all differed from human HFpEF. Thus, human HFpEF myocardium has distinctive cardiac lipid accumulation not found with obesity alone or HFrEF, nor mirrored by common preclinical HFpEF models.

Indexed as

acylcarnitinescardiolipinceramidesHFpEFHFrEFlipotoxicitymetabolic remodelingmyocardial lipidomics

Identifiers

PMID42523454
PMCPMC13405474

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.