Evidence map›Paper›PMID 42523692›Full record

SynthesisFrontiers in public health2026

Nonlinear dose-response effects of exercise interventions on post-stroke depression: a systematic review and meta-analysis.

Meiyao Liu, Ziqi Gao, Yaxin Wang, Huimin Yang, Chang Liu, Jiahe Wu, Shenghui Liang, Shiyue Shao, Ziheng Zhang, Jianxin Kang and 1 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Meiyao LiuGraduate School, Harbin Sport University, Harbin, China.
Ziqi GaoGraduate School, Harbin Sport University, Harbin, China.
Yaxin WangGraduate School, Harbin Sport University, Harbin, China.
Huimin YangGraduate School, Harbin Sport University, Harbin, China.
Chang LiuGraduate School, Harbin Sport University, Harbin, China.
Jiahe WuGraduate School, Harbin Sport University, Harbin, China.
Shenghui LiangGraduate School, Harbin Sport University, Harbin, China.
Shiyue ShaoGraduate School, Harbin Sport University, Harbin, China.
Ziheng ZhangGraduate School, Harbin Sport University, Harbin, China.
Jianxin KangGraduate School, Harbin Sport University, Harbin, China.
Xin LiuGraduate School, Harbin Sport University, Harbin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To systematically evaluate the effects of exercise interventions on post-stroke depression (PSD) and to clarify the dose-response relationship between physical activity dosage and depressive symptoms in individuals with PSD. Methods: A structured and comprehensive search was conducted in PubMed, Web of Science, Embase, Scopus, and the Cochrane Library. Restricted cubic spline models were applied to examine the dose-response association between physical activity dosage and depressive symptoms in PSD. Results: A total of 27 publications comprising 31 randomized controlled trials were included, involving 2,247 participants. The meta-analysis indicated that exercise intervention was associated with a modest improvement in depressive symptoms among patients with PSD [SMD = -0.15, 95% CI (-0.23, -0.07), Conclusion: Moderate-dose exercise intervention, approximately 801 MET-min/week, was associated with a modest improvement in post-stroke depressive symptoms. These findings provide a reference for optimizing exercise dosage and informing individualized prescription strategies for patients with PSD. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251167322, identifier (CRD420251167322).

Indexed as

DepressionExerciseExercise TherapyStrokeStroke RehabilitationHumansRandomized Controlled Trials as Topicdose–response relationshipexercise interventionmeta-analysismetabolic equivalentpost-stroke depression

Identifiers

PMID42523692
PMCPMC13407525

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.