Evidence map›Paper›PMID 42523772›Full record

ArticleFrontiers in immunology2026

Association of the methylation of age-related epigenetic marker ELOVL2 with neurophysiological alterations and immunosenescence during aging and its modulation by the APOE genotype.

Natalya V Ponomareva, Irina L Kuznetsova, Viktoria Petrova, Tatiana V Andreeva, Maria S Protasova, Rodion N Konovalov, Marina Krotenkova, Daria D Malina, Ekaterina Kolesnikova, Elena Kanavets and 9 more

Abstract read
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In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Natalya V PonomarevaRussian Center of Neurology and Neurosciences, Moscow, Russia.
Irina L KuznetsovaVavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia.
Viktoria PetrovaCenter for Genetics and Life Science, Sirius University of Science and Technology, Sochi, Russia.
Tatiana V AndreevaVavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia.
Maria S ProtasovaCenter for Genetics and Life Science, Sirius University of Science and Technology, Sochi, Russia.
Rodion N KonovalovRussian Center of Neurology and Neurosciences, Moscow, Russia.
Marina KrotenkovaRussian Center of Neurology and Neurosciences, Moscow, Russia.
Daria D MalinaRussian Center of Neurology and Neurosciences, Moscow, Russia.
Ekaterina KolesnikovaRussian Center of Neurology and Neurosciences, Moscow, Russia.
Elena KanavetsRussian Center of Neurology and Neurosciences, Moscow, Russia.
Daria KuprianovaCenter for Genetics and Life Science, Sirius University of Science and Technology, Sochi, Russia.
Andrey MitrofanovResearch Center of Mental Health, Moscow, Russia.
Julia D VavilovaShemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Anna A BoykoShemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Elena I KovalenkoShemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Alexander M SapozhnikovShemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Vitaly F FokinRussian Center of Neurology and Neurosciences, Moscow, Russia.
Sergey N IllarioshkinRussian Center of Neurology and Neurosciences, Moscow, Russia.
Evgeny I RogaevCenter for Genetics and Life Science, Sirius University of Science and Technology, Sochi, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: DNA methylation of the Methods: We examined 72 non-demented volunteers aged 20-88 years, stratified by Results: Conclusion: The results imply a close link between

Indexed as

AgingApolipoproteins EBrainDNA MethylationEpigenesis, GeneticFatty Acid ElongasesImmunosenescenceAdultAgedAged, 80 and overBiomarkersFemaleGenotypeHumansMagnetic Resonance ImagingMaleApolipoproteins EBiomarkersELOVL2 protein, humanFatty Acid ElongasesagingAPOE genotypeELOVL2 methylationevent-related potentialsfunctional MRIimmunosenescence

Identifiers

PMID42523772
PMCPMC13407353

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.