Evidence map›Paper›PMID 42523809›Full record

ArticleFrontiers in psychiatry2026

C-reactive protein polygenic risk is associated with obesity-related traits in schizophrenia spectrum disorders.

Chenxu Zhao, Elnaz Naderi, Tesfa Dejenie Habtewold, Therese van Amelsvoort, Wiepke Cahn, Lieuwe de Haan, Marieke van der Pluijm, Claudia J P Simons, Jim van Os, Wim Veling and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chenxu ZhaoDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Elnaz NaderiDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Tesfa Dejenie HabtewoldDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Therese van AmelsvoortDepartment of Psychiatry and Neuropsychology, Maastricht University Medical Center, School for Mental Health and Neuroscience, Maastricht, Netherlands.
Wiepke CahnBrain Centre Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Lieuwe de HaanDepartment of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
Marieke van der PluijmDepartment of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
Claudia J P SimonsDepartment of Psychiatry and Neuropsychology, Maastricht University Medical Center, School for Mental Health and Neuroscience, Maastricht, Netherlands.
Jim van OsBrain Centre Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Wim VelingDepartment of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Richard BruggemanDepartment of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Behrooz Z AlizadehDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Patients with schizophrenia spectrum disorders (SSDs) are at increased risk of cardiometabolic dysregulations, which substantially contribute to cardiovascular morbidity and reduced life expectancy. Chronic low-grade inflammation is a key factor in the development of cardiometabolic outcomes. Polygenic risk scores (PRS) for inflammatory biomarkers like for C-reactive protein (CRP) and interleukin 6 (IL-6) may help clarify the genetic contribution to this risk, yet evidence in SSDs populations remains limited. Methods: We investigated the associations of PRSes for CRP and IL6 with cardiometabolic outcomes in 671 patients with SSDs from the longitudinal Dutch Genetic Risk and Outcome in Psychosis (GROUP) study. Seven PRS Results: Higher standardized PRS Conclusions: Higher genetic susceptibility for low grade inflammation as captured by PRS

Indexed as

cardiometabolic outcomeC-reactive proteininterleukin 6obesity-related traitspolygenic risk scoreschizophrenia spectrum disorders

Identifiers

PMID42523809
PMCPMC13407836

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.