ArticleFrontiers in aging neuroscience2026
Multivariate associations between systemic inflammation, metabolic dysregulation, and cognitive performance in project FRONTIER.
Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Cognitive aging is heterogeneous, and growing evidence implicates chronic low-grade inflammation and metabolic dysregulation in neuropathology and cognitive decline. This study examined the multivariate relationship between inflammatory-metabolic biomarkers and neuropsychological performance in a large, community-based cohort of adults from rural West Texas enrolled in Project FRONTIER. Methods: Participants aged ≥ 40 years who completed a study visit in the Project FRONTIER study were included ( Results: CCA revealed a significant multivariate association between inflammatory-metabolic biomarkers and cognitive performance. The first canonical correlation was 0.242 (95% CI: 0.171-0.310), accounting for 5.8% of the shared variance between the biological and cognitive domains. This association was statistically significant based on both Wilks' lambda ( Conclusion: Systemic inflammation and metabolic dysregulation were associated with poorer cognitive performance, particularly executive dysfunction, in this rural aging cohort. These findings, while modest in effect size, support the importance of cardiometabolic health in cognitive aging, motivating future longitudinal and mechanistic studies.
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