ArticleFrontiers in nutrition2026
Association between the uric acid to high-density lipoprotein cholesterol ratio and estimated glomerular filtration rate decline in community-managed patients with type 2 diabetes: a retrospective cohort study.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The uric acid to high-density lipoprotein cholesterol ratio (UHR), a composite biomarker integrating pro-inflammatory stress and vascular protection loss, has been linked to diabetic kidney disease (DKD) in cross-sectional studies, but longitudinal evidence on its association with continuous eGFR decline remains limited. Methods: This retrospective cohort study included 8,827 community-managed type 2 diabetes patients from 54 health centers in Shenzhen, China, followed for 3 years (2023-2025). Baseline UHR was calculated as serum uric acid (μmol/L) divided by HDL-C (mmol/L). The primary outcome was annual eGFR slope, derived from individual linear regressions. Multivariable linear regression, restricted cubic spline analysis, model comparison, and pre-specified subgroup and sensitivity analyses were performed. Results: In fully adjusted models, each 1-unit increase in baseline UHR was associated with greater annual eGFR decline ( Conclusion: Higher baseline UHR independently predicted faster eGFR decline in community-managed type 2 diabetes patients. As an inexpensive, readily available index, UHR may serve as a biomarker for identifying patients at elevated risk of progressive renal function loss.
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