ReviewFrontiers in bioengineering and biotechnology2026
Analysis of biological systems using bioimpedance spectroscopy: a critical review of technological convergence and translational challenges.
Review in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bioimpedance spectroscopy (BIS) has emerged as a versatile, non-invasive technique for real-time electrical characterization of biological systems. By applying alternating current and analyzing the resulting complex impedance, BIS provides insights into cellular structure, tissue properties, and physiological processes, and can also detect pathogenic bacteria. This article presents a scoping review of recent advances in BIS, conducted under the Arksey and O'Malley framework and PRISMA-ScR guidelines, and analyzes 46 studies published between 2015 and 2025 that address BIS applications across biological systems. The strongest evidence was identified in fluid management and hydration monitoring (39.1%), body composition assessment (17.4%), and lymphedema monitoring (15.2%), whereas applications in tissue characterization, cellular systems, agriculture, machine learning-assisted diagnostics, and biosensing technologies remain at lower levels of translational maturity. Recent advances in instrumentation, sensor design, microfluidics, wearable systems, and computational analysis are critically examined. The review identifies major technological barriers, including a lack of standardized acquisition protocols, device-dependent variability, limited interoperability, heterogeneous modeling approaches, and insufficient multicenter validation. Despite challenges related to standardization, modeling of heterogeneous systems, and measurement reproducibility, BIS continues to demonstrate potential across biomedical, biotechnological, and industrial applications. Its ability to provide continuous, real-time, and non-destructive measurements supports its growing use in diagnostic platforms, therapeutic monitoring, and industrial biosensing applications. This review provides an integrated perspective on current developments, limitations, and future directions of BIS-based technologies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.